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首页> 外文期刊>Journal of drug research. >Assessment of the Protective Role of Green Tea on Doxorubicin Induced Hepatic and Renal Injuries in Albino Rats
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Assessment of the Protective Role of Green Tea on Doxorubicin Induced Hepatic and Renal Injuries in Albino Rats

机译：绿茶对阿霉素诱导的白化大鼠肝肾损伤的保护作用评估

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The present study has been undertaken to investigate the ameliorative effect of green tea (GT) on doxorubicin (Doxo)-induced hepatotoxicity and nephrotoxicity in albino rats. The harmful effects of Doxo on some antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD) and glutathione-S-transferase (GST) were studied . Reduced glutathione (GSH) and malondialdehyde (MDA) in liver and kidney homogenates were investigated. Quantitative and qualitative extents of DNA damage in the liver cells were also estimated using Comet assay. Thirty two male adult albino rats (180-200 g) were divided into four groups (n=8) as follows: (1) Control group: was orally administered 1 ml/rat of 0.5% carboxymethyl cellulose (CMC) in distilled water, (2) Doxo group: after 10 days, Doxo was administered a single i.p. dose of 15 mg/kg body weight, (3) GT group: rats received 100 mg/kg body weight, p.o. of GT for 10 days and (4) Doxo and GT group: rats received 100 mg/kg body weight, p.o. of GT for 10 days prior to Doxo administration as a single i.p. dose of 15 mg/kg body weight. Doxorubicin-induced significant increase in serum levels of AST, ALT and y-glutamyl transpeptidase (GGT) for liver and urea and creatinine for kidney which were decreased by pretreatment with GT. Total serum protein and albumin levels were decreased after treatment with Doxo but this effect was attenuated by pretreatment with GT. Catalase, SOD, GST activities and GSH content of liver and kidney were significantly elevated by pretreatment with GT compared to Doxo-treated rats. Doxorubicin significantly increased MDA levels in liver and kidney homogenates, while pretreatment with GT blunted the increase in MDA levels. DNA damage measured as tail length, tail DNA % and tail moment were increased after treatment of Doxo while pretreatment with GT improved this effect. This study suggests that green tea has potential protective effect against doxorubicin-induced hepatoxicity and nephrotoxicity. So, it may be worthy to consider the usefulness of GT as adjuvant therapy in cancer management.
机译：进行本研究以研究绿茶（GT）对阿霉素引起的阿霉素（Doxo）肝毒性和肾毒性的改善作用。研究了Doxo对某些抗氧化酶，过氧化氢酶（CAT），超氧化物歧化酶（SOD）和谷胱甘肽S-转移酶（GST）的有害作用。研究了肝脏和肾脏匀浆中还原型谷胱甘肽（GSH）和丙二醛（MDA）的变化。肝细胞中DNA损伤的定量和定性程度也使用Comet分析进行了估计。将32只成年白化病雄性大鼠（180-200 g）分为四组（n = 8），如下：（1）对照组：在蒸馏水中口服1 ml /大鼠0.5％羧甲基纤维素（CMC）， （2）Doxo组：10天后，给Doxo一次腹膜内注射剂量为15 mg / kg体重，（3）GT组：大鼠接受100 mg / kg体重，口服。 10天的GT训练和（4）Doxo和GT组：大鼠接受100 mg / kg体重，口服。在Doxo给药之前，以10天的时间服用GT。剂量为15 mg / kg体重。阿霉素诱导的肝脏血清AST，ALT和γ-谷氨酰转肽酶（GGT）血清水平显着升高，肾脏的尿素和肌酐水平显着升高，而GT预处理可降低这些水平。用Doxo治疗后总血清蛋白和白蛋白水平降低，但GT预处理减弱了这种作用。与Doxo处理的大鼠相比，GT预处理显着提高了肝脏和肾脏的过氧化氢酶，SOD，GST活性和GSH含量。阿霉素显着增加了肝脏和肾脏匀浆中的MDA水平，而GT预处理则抑制了MDA水平的增加。用Doxo处理后，以尾巴长度，尾巴DNA％和尾巴矩衡量的DNA损伤增加，而GT预处理则改善了这种效果。这项研究表明，绿茶对阿霉素诱导的肝毒性和肾毒性具有潜在的保护作用。因此，可能有必要考虑将GT用作癌症治疗中的辅助治疗方法。

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