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首页> 外文期刊>Journal of drug research. >Modulation the Oxidant - Antioxidant Imbalance Induced By Thioacetamide in Liver of Albino Rats
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Modulation the Oxidant - Antioxidant Imbalance Induced By Thioacetamide in Liver of Albino Rats

机译：调节硫乙酰胺诱导的白化大鼠肝脏氧化-抗氧失衡。

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摘要

The effect of free radicals on human beings has come to attract considerable attention due to their close relation to toxicity and disease. The aim of the present investigation is to evaluate the antioxidant efficacy of fresh garlic extract (FGE), aged garlic extract (AGE) and ginger ethanolic extract (GEE) against the oxidative stress induced by thioacetamide administration. Silymarin and Hipamax plus (HP) were employed in the current study as reference materials used in the treatment of liver diseases. Intraperitoneal (ip) administration of thioacetamide (200 mg / kg b.wt., three times a week for four weeks) induced oxidative stress that confirmed by the significant elevation of malondialdehyde (MDA, as an indicator of lipid peroxidation), nitric oxide (NO), myeloperoxidase activity (MPO) with the decline in glutathione content (GSH) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione S-transferase (GST) in liver tissue. Meanwhile, there was no change in protein carbonyl. The pre and со - administration of fresh garlic extract, aged garlic extract and ginger ethanolic extract with thioacetamide significantly reduced MDA, NO, MPO activity and enhanced the activity of SOD , GSHPx, GST and markedly increase GSH content in liver tissue. In conclusion: the test materials employed in the current study displayed well marked antioxidant potency and more pronounced antioxidant potency was exerted by AGE.
机译：自由基对人体的影响由于其与毒性和疾病的密切关系而引起了人们的极大关注。本研究的目的是评估新鲜大蒜提取物（FGE），陈年大蒜提取物（AGE）和生姜乙醇提取物（GEE）的抗氧化功效，以对抗由硫代乙酰胺引起的氧化应激。在本研究中，水飞蓟素和Hipamax plus（HP）被用作治疗肝脏疾病的参考材料。腹膜内（ip）施用硫代乙酰胺（200 mg / kg体重，每周三次，共四周）诱导了氧化应激，丙二醛（MDA，作为脂质过氧化的指标），一氧化氮（ NO），髓过氧化物酶活性（MPO）随肝组织中谷胱甘肽含量（GSH）和超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSHPx），谷胱甘肽S-转移酶（GST）的下降而降低。同时，蛋白质羰基没有变化。新鲜大蒜提取物，陈年大蒜提取物和生姜乙醇提取物与硫代乙酰胺的预施用和施用可显着降低MDA，NO，MPO活性，并增强SOD，GSHPx，GST的活性，并显着增加肝脏组织中GSH的含量。结论：当前研究中使用的测试材料显示出明显的抗氧化剂效能，而AGE发挥了更明显的抗氧化剂效能。

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