...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of drug assessment >Impact on health outcome and costs of influenza treatment with oseltamivir in elderly and high-risk patients
【24h】

Impact on health outcome and costs of influenza treatment with oseltamivir in elderly and high-risk patients

机译：奥司他韦对老年和高危患者的健康结局和流感治疗费用的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The main objective of this study was to evaluate health outcomes and costs to the healthcare payer of treating influenza with oseltamivir in a high-risk population. Data from published literature, clinical trials and public sources were used to develop a decision-analytic model simulating a high-risk population in the UK. The underlying clinical pathway predicts morbidity and mortality due to influenza, and its specified complications for the two influenza treatment strategies梠seltamivir and usual care. Health outcomes (quality-adjusted life years [QALYs], days to return to normal activity) and costs were estimated for events in the model. Robustness of the results was tested by probabilistic, univariate and multivariate sensitivity analyses.Treatment with oseltamivir within 48 hours results in reduced morbidity, which translates into faster recovery and return to normal activity. Economic evaluation showed that treatment with oseltamivir in a high-risk population in the UK is a cost-effective strategy in all analysed scenarios with cost-utility ratios between ?25 and ?7,900 per QALY gained.Treatment with oseltamivir is effective in terms of health outcome and cost for high-risk patients from the perspectives of the individual patient and healthcare payer.# 1
机译：这项研究的主要目的是评估在高危人群中使用奥司他韦治疗流感的健康结果和医疗保健付款方的费用。来自公开文献，临床试验和公共资源的数据被用于开发决策分析模型，以模拟英国的高危人群。基本的临床途径可预测由流感引起的发病率和死亡率，以及两种流感治疗策略-舍他米韦和常规治疗所指定的并发症。对模型中事件的健康结果（质量调整生命年[QALYs]，恢复正常活动的天数）和成本进行了估算。结果的稳健性通过概率，单因素和多因素敏感性分析进行了测试。在48小时内用奥司他韦治疗可降低发病率，这意味着更快的恢复并恢复了正常活动。经济评估表明，在所有分析的情况下，在所有高危人群中使用奥司他韦治疗都是一种具有成本效益的策略，每QALY获得的成本-效用比在25至7,900之间。就健康而言，奥司他韦治疗是有效的从单个患者和医疗支付者的角度来看，高风险患者的结果和费用。＃1

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号