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首页> 外文期刊>Journal of drug delivery science and technology >Nanoparticles based on quaternary ammonium-chitosan conjugate: A vehicle for oral administration of antioxidants contained in red grapes
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Nanoparticles based on quaternary ammonium-chitosan conjugate: A vehicle for oral administration of antioxidants contained in red grapes

机译：基于季铵-壳聚糖共轭物的纳米颗粒：一种用于红葡萄中抗氧化剂口服的载体

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The purpose of this study was to demonstrate that nanoparticles (NP), obtained by ionotropic cross linking of reduced-MW chitosan (rCh) derivatives with reduced-MW hyaluronan (rHA), could be profitable vehicles for oral administration of beneficial doses of antioxidant constituents of red grape seeds extracts (GSE). NP have previously shown aptitude for internalisation by endothelial progenitor cells. Here they were seen by a fluorescence microscope migrating across excised rat intestine from mucosal to serosal side and permeating from the donor to the acceptor compartment of an Ussing chamber while carrying significant (15-20%) steadily associated fractions of initial antioxidant load. Freshly prepared NP dispersions were stabilised by lyophilisation. The NP dispersions were regenerated from the lyophilised products by adding water under gentle stirring. Lyophilisation-regeneration caused a significant NP size increase yet particles did not grow beyond the upper size limit of particles able to cross the intestinal barrier (500 nm). (C) 2015 Published by Elsevier B.V.
机译：这项研究的目的是证明，通过还原MW的壳聚糖（rCh）衍生物与还原MW的乙酰透明质酸（rHA）的离子交联获得的纳米颗粒（NP）可能是口服口服有益剂量的抗氧化剂成分的有利载体。红葡萄籽提取物（GSE）。 NP以前已经显示出可以被内皮祖细胞内在化。在这里，通过荧光显微镜可以看到它们从黏膜到浆膜侧跨过切除的大鼠肠，从供体渗透到Usssing室的接受区，同时承载着稳定的初始抗氧化剂部分（15-20％）。通过冻干使新鲜制备的NP分散体稳定。通过在缓慢搅拌下加水，从冻干产物中再生NP分散体。冻干再生导致NP大小显着增加，但颗粒并未超过能够穿过肠屏障的颗粒大小上限（500 nm）。 （C）2015由Elsevier B.V.发布

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