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首页> 外文期刊>Journal of drug delivery science and technology >Drug and protein delivery by polymer conjugation
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Drug and protein delivery by polymer conjugation

机译：通过聚合物偶联来递送药物和蛋白质

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Drug and protein delivery techniques and methods, which, in most cases, are concurrently investigated from the very time a new molecular entity is proposed, have become valuable tools for the development of numerous therapeutic molecules. Attracting the attention of academia and industrial researchers, several polymer conjugation methodologies have been shown to have a wide range of applications and a success rate that have been confirmed by the numerous conjugates already in clinical use or under investigation in on-going clinical trials. Having attained a high level of sophistication, this technology is able to generate homogeneous conjugates by exploiting specifically designed coupling strategies (based, for example, on the use of enzymes), which ensure good product characterization, high activity retention, and batch-to-batch reproducibility. Poly(ethylene glycol) (PEG), which is the current gold standard for stealth polymers in the emerging field of polymer-based drug delivery, is in competition with other polymers that have convenient features such as biodegradability. PEG still holds first place as far as PEGylated derivatives under investigation in clinical trials are concerned, and it will presumably remain the polymer of choice even in the future as further improvements such as the development of new copolymers based on PEG or PEG derivatives will overcome for example the hurdle of biodegradability. (C) 2015 Elsevier B.V. All rights reserved.
机译：在大多数情况下，从提出新分子实体的那一刻起，就同时研究了药物和蛋白质的输送技术和方法，这些技术和方法已成为开发众多治疗性分子的宝贵工具。吸引了学术界和工业研究人员的注意力，几种聚合物偶联方法已显示出广泛的应用和成功率，已被临床使用或正在进行的临床试验中的众多偶联物所证实。该技术已达到很高的成熟度，它能够通过利用专门设计的偶联策略（例如基于酶的使用）来生成均质的偶联物，从而确保良好的产品表征，高活性保留和逐批生产。批次重现性。聚乙二醇（PEG）是在基于聚合物的药物递送这一新兴领域中隐形聚合物的当前金标准，它正在与具有诸如生物降解性等便利功能的其他聚合物竞争。就临床试验中研究的聚乙二醇化衍生物而言，聚乙二醇仍居首位，即使在将来，聚乙二醇仍将是首选聚合物，因为进一步的改进，例如基于聚乙二醇或聚乙二醇衍生物的新共聚物的开发将克服例如可生物降解的障碍。 （C）2015 Elsevier B.V.保留所有权利。

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