Polymeric alginate nanoparticles containing the local anesthetic bupivacaine.

Grillo R; de Melo NF; de Araujo DR; de Paula E; Rosa AH; Fraceto LF

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Polymeric alginate nanoparticles containing the local anesthetic bupivacaine.

机译：含有局部麻醉药布比卡因的聚合藻酸盐纳米颗粒。

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Bupivacaine (BVC; S75-R25, NovaBupi(R) is an amide-type local anesthetic. Sodium alginate is a water-soluble linear polysaccharide. The present study reports the development of alginate/bis(2-ethylhexyl) sulfosuccinate (AOT) and alginate/chitosan nanoparticle formulations containing BVC (0.5%). The amounts of BVC associated in the alginate/AOT and alginate/chitosan nanoparticles were 87 +/- 1.5 and 76 +/- 0.9%, respectively. The average diameters and zeta potentials of the nanoparticles were measured for 30 days, and the results demonstrated the good stability of these particles in solution. The in vitro release kinetics showed a different behavior for the release profile of BVC in solution, compared with BVC-loaded alginate nanoparticles. In vitro and in vivo assays showed that alginate-chitosan BVC (BVC(ALG-CHIT)) and alginate-AOT BVC (BVC(ALG-AOT)) presented low cytotoxicity in 3T3-fibroblasts, enhanced the intensity, and prolonged the duration of motor and sensory blockades in a sciatic nerve blockade model.

机译：布比卡因（BVC; S75-R25，NovaBupi®是一种酰胺型局麻药。海藻酸钠是一种水溶性线性多糖。本研究报告了海藻酸钠/双（2-乙基己基）磺基琥珀酸酯（AOT）和含BVC（0.5％）的藻酸盐/壳聚糖纳米颗粒制剂，藻酸盐/ AOT和藻酸盐/壳聚糖纳米颗粒中缔合的BVC量分别为87 +/- 1.5和76 +/- 0.9％。测量了30天的纳米颗粒，结果证明了这些颗粒在溶液中的良好稳定性;与负载BVC的藻酸盐纳米颗粒相比，体外释放动力学显示溶液中BVC的释放曲线具有不同的行为。体内试验表明，藻酸盐-壳聚糖BVC（BVC（ALG-CHIT））和藻酸盐-AOT BVC（BVC（ALG-AOT））在3T3-成纤维细胞中表现出低细胞毒性，增强强度，并延长运动和感觉的持续时间在SC中的封锁睫状神经阻滞模型。

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《Journal of drug targeting》 |2010年第9期|共12页
作者
Grillo R; de Melo NF; de Araujo DR; de Paula E; Rosa AH; Fraceto LF;
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中图分类药学;
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1. Polymeric alginate nanoparticles containing the local anesthetic bupivacaine. [J] . Grillo R, de Melo NF, de Araujo DR, Journal of drug targeting . 2010,第9期

机译：含有局部麻醉药布比卡因的聚合藻酸盐纳米颗粒。
2. Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles, which performed better for local anesthetic therapy? [J] . Min Li, Shuo Feng, Huaixin Xing, Drug delivery. . 2020,第1期

机译：德克梅哌啶胺和左旋普替昔芬肽加载转录转段肽肽改性纳米结构脂质载体或脂质 - 聚合物杂交纳米颗粒，对局部麻醉治疗表现较好吗？
3. pAn efficient and long-acting local anesthetic: ropivacaine-loaded lipid-polymer hybrid nanoparticles for the control of pain/p [J] . Aimei Li, Feng Yang, Jiaying Xin, International Journal of Nanomedicine . 2019,第1期

机译：>一种高效和长效的局部麻醉：加载Ropivaine加载的脂质 - 聚合物杂交纳米粒子，用于控制疼痛
4. Tuning the Presentation and Density of Targeting Peptides on Polymeric Nanoparticles to Improve Bone Localization [C] . Marian Ackun-Farmmer, Yifei Yan, David Fraser, Society for Biomaterials annual meeting and exposition . 2019

机译：调整高分子纳米颗粒上靶向肽的表达和密度以改善骨定位
5. Polymeric drug delivery systems: Lidocaine microspheres for prolonged and localized in vivo anesthetic effects and light-induced drug release from polymeric device mediated by bacteriorhodopsin. [D] . Chen, Pen-Chung. 2004

机译：聚合物药物递送系统：利多卡因微球可延长和定位体内麻醉作用，并由细菌视紫红质介导的光诱导药物从聚合物装置中释放。
6. Dexmedetomidine and levobupivacaine co-loaded transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles which performed better for local anesthetic therapy? [O] . Min Li, Shuo Feng, Huaixin Xing, 2020

机译：德克梅哌啶胺和左旋普替昔芬肽加载转录转段肽肽改性纳米结构脂质载体或脂质 - 聚合物杂交纳米颗粒对局部麻醉治疗表现较好吗？
7. An alternative choice of lidocaine-loaded liposomes: lidocaine-loaded lipid–polymer hybrid nanoparticles for local anesthetic therapy [O] . Jianguo Wang, Laizhu Zhang, Huimin Chi, 2016

机译：LIDOCAINE加载脂质体的替代选择：LIDOCAINE加载的脂质 - 聚合物杂交纳米粒子用于局部麻醉治疗

Polymeric alginate nanoparticles containing the local anesthetic bupivacaine.

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