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首页> 外文期刊>Journal of applied microbiology >In vitro activity of allicin against Staphylococcus epidermidis and influence of subinhibitory concentrations on biofilm formation
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In vitro activity of allicin against Staphylococcus epidermidis and influence of subinhibitory concentrations on biofilm formation

机译：大蒜素对表皮葡萄球菌的体外活性及亚抑制浓度对生物膜形成的影响

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摘要

Aims: The aim of this study is to determine the in vitro activity of allicin against Staphylococcus epidermidis and to evaluate the influence of allicin on biofilm formation. Methods and Results: In vitro activity of allicin (diallyl thiosulphinate) against 38 strains of S. epidermidis was investigated. The activity of allicin was similar against S. epidermidis methicillin susceptible and methicillin resistant strains [minimum inhibitory concentration (MIC)_(90) = 8 mg l~(-1)]. In general, subinhibitory concentrations (sub-MIC) of allicin diminished biofilm formation in the five strains analysed. Conclusion: The results confirm the antibacterial effect of allicin. Sub-MICs of allicin also diminished the biofilm formations by S. epidermidis. Significance and Impact of the Study: The present study shows that allicin is active in vitro against S. epidermidis and that sub-MICs of allicin may play a role in the prevention of adherence of this bacteria to medical devices.
机译：目的：本研究的目的是确定大蒜素对表皮葡萄球菌的体外活性，并评估大蒜素对生物膜形成的影响。方法和结果：研究了大蒜素（二烯丙基硫代硫酸盐）对表皮葡萄球菌38株的体外活性。大蒜素对表皮葡萄球菌易感和耐甲氧西林的菌株具有相似的活性[最低抑菌浓度（MIC）_（90）= 8 mg l〜（-1）]。通常，大蒜素的亚抑制浓度（sub-MIC）减少了所分析的五种菌株中生物膜的形成。结论：结果证实了大蒜素的抗菌作用。大蒜素的亚MIC还减少了表皮葡萄球菌的生物膜形成。该研究的意义和影响：本研究表明，大蒜素在体外具有对抗表皮葡萄球菌的活性，并且大蒜素的亚MIC可能在预防这种细菌与医疗器械的粘附中发挥作用。

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