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首页> 外文期刊>Clinical chemistry and laboratory medicine: CCLM >Polymorphic mononuclear neutrophils CD64 index for diagnosis of sepsis in postoperative surgical patients and critically ill patients.
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Polymorphic mononuclear neutrophils CD64 index for diagnosis of sepsis in postoperative surgical patients and critically ill patients.

机译：多态性单核细胞嗜中性粒细胞CD64指数可用于诊断术后手术患者和危重患者的败血症。

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Surface neutrophil CD64 expression is upregulated in patients with bacterial infection. As it was suggested that the CD64 index could be used to detect sepsis in hospitalized patients, we questioned whether the CD64 index could discriminate between septic patients and postoperative surgical patients, defined as systemic inflammatory response syndrome (SIRS), both admitted at the intensive care unit (ICU). Furthermore, we wondered whether the CD64 index was an improved diagnostic compared to standard assays used at the laboratory. For this, outclinic (OC) patients were included as controls.The Leuko64? assay was used to determine the CD64 index in residual EDTA blood samples from selected septic patients (n=25), SIRS patients (n=19), and OC patients (n=24). Additionally, WBC count, neutrophilic and eosinophilic granulocyte count, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured simultaneously.The CD64 index was higher in septic patients compared to both the SIRS and OC group (p<0.0001). In addition, the WBC count, neutrophil count, ESR and CRP were also higher in septic patients than the OC group (p<0.0001). However, only the WBC count, eosinopenia, and ESR were comparable between the SIRS and the sepsis group and proved to be discriminative to the OC group (p<0.05). The CD64 index demonstrated higher sensitivity and specificity than CRP, WBC count, neutrophilic and eosinophilic granulocyte count, and ESR.A high CD64 index was found in septic intensive care patients, while a low CD64 index was observed in OC and SIRS patients, demonstrating that the CD64 index can be used for routine diagnostics in the ICU setting.
机译：细菌感染患者的表面中性粒细胞CD64表达上调。由于有人建议CD64指数可用于检测住院患者的败血症，因此我们质疑CD64指数能否区分败血症患者和术后手术患者，均被定义为系统性炎症反应综合征（SIRS），两者均在重症监护室就诊单位（ICU）。此外，我们想知道与实验室使用的标准测定相比，CD64指数是否可以改善诊断水平。为此，将外来（OC）患者作为对照。该分析用于确定来自选定脓毒症患者（n = 25），SIRS患者（n = 19）和OC患者（n = 24）的残留EDTA血液样本中的CD64指数。此外，同时测量WBC计数，嗜中性粒细胞和嗜酸性粒细胞计数，C反应蛋白（CRP）和红细胞沉降率（ESR）。与SIRS和OC组相比，脓毒症患者的CD64指数更高（p <0.0001） 。此外，败血症患者的白细胞计数，中性粒细胞计数，ESR和CRP也高于OC组（p <0.0001）。但是，SIRS和败血症组之间只有WBC计数，嗜曙红细胞减少症和ESR是可比的，并被证明与OC组有区别（p <0.05）。 CD64指数显示出比CRP，WBC计数，嗜中性粒细胞和嗜酸性粒细胞计数和ESR更高的敏感性和特异性。败血症重症监护患者CD64指数较高，而OC和SIRS患者CD64指数较低。 CD64索引可用于ICU设置中的常规诊断。

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