Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots

Baldelli Sara; Cattaneo Dario; Giodini Luciana; Baietto Lorena; Di Perri Giovanni; DAvolio Antonio; Clementi Emilio

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Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots

机译：HPLC-UV方法的开发和验证，该方法用于定量干燥血浆斑点中的抗癫痫药

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Background: Therapeutic drug monitoring (TDM) of antiepileptic drugs is widely used in clinical practice to optimise therapy, but it is limited by technical problems and cost considerations. The aim of the present study was: 1) to validate a chromatographic method for the concomitant determination of levetiracetam, lamotrigine, ethosuximide, felbamate, rufinamide, zonisamide and monohydroxycarbamazepine; 2) to develop it for dried plasma spot (DPS) assessing its reliability against the classical determination from plasma; and 3) test its clinical application.

机译：背景：抗癫痫药的治疗药物监测（TDM）在临床实践中广泛用于优化治疗，但受到技术问题和成本考虑的限制。本研究的目的是：1）验证色谱法同时测定左乙拉西坦，拉莫三嗪，乙硫磺酰亚胺，非巴马特，鲁芬酰胺，唑尼沙胺和单羟基卡马西平; 2）开发用于干血浆斑点（DPS）的产品，评估其抗血浆经典测定的可靠性; 3）测试其临床应用。

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《Clinical chemistry and laboratory medicine: CCLM》 |2015年第3期|共10页
作者
Baldelli Sara; Cattaneo Dario; Giodini Luciana; Baietto Lorena; Di Perri Giovanni; DAvolio Antonio; Clementi Emilio;
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正文语种 eng
中图分类诊断学;
关键词
antiepileptic drugs; dried plasma spots; high performance liquid chomatography;

机译：抗癫痫药;血浆干斑;高效液相色谱;

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1. Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots [J] . Baldelli Sara, Cattaneo Dario, Giodini Luciana, Clinical chemistry and laboratory medicine: CCLM . 2015,第3期

机译：HPLC-UV方法的开发和验证，该方法用于定量干燥血浆斑点中的抗癫痫药
2. Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma [J] . Franco Valentina, Marchiselli Roberto, Fattore Cinzia, Therapeutic Drug Monitoring . 2016,第6期

机译：HPLC-UV测定法在人血浆中治疗性抗癫痫新药Perampanel的治疗监测中的开发和验证
3. Development and validation of an UPLC-PDA method to quantify daptomycin in human plasma and in dried plasma spots [J] . BaiettoL., DAvolioA., PaceS., Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2014,第Null期

机译：开发和验证用于定量人血浆和干燥血浆斑点中达托霉素的UPLC-PDA方法
4. Development and validation of an UHPLC-MS/MS method to quantify imatinib, desmethylimatinib, dasatinib, nilotinib and ponatinib in dried plasma spots [C] . Alessandra Ariaudo, Marco Simiele, Fabio Favata, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：UHPLC-MS / MS方法的开发和验证量化伊马替尼，去甲基氨基啶，Dasatinib，尼洛尼布和Ponatinib在干等离子体斑点中的方法
5. Development of Newborn Screening Methods for Mucopolysaccharidosis III Type A and Type B in Dried Blood Spot Using Tandem Mass Spectrometry [D] . Yi, Fan. 2018

机译：使用串联质谱法，在干血液点粘性型A和型B型和型B的新生筛查方法的开发
6. Development validation and clinical application of a method for the simultaneous quantification of lamivudine emtricitabine and tenofovir in dried blood and dried breast milk spots using LC–MS/MS [O] . Catriona Waitt, Sujan Diliiy Penchala, Adeniyi Olagunju, -1

机译：LC-MS / MS同时测定干血和干乳斑点中拉米夫定恩曲他滨和替诺福韦的方法的开发验证和临床应用
7. Development and validation of a new method to simultaneously quantify triazoles in plasma spotted on dry sample spot devices and analysed by HPLC-MS [O] . L. Baietto, A. DAvolio, C. Marra, 2012

机译：一种新方法的开发和验证在干燥样品点装置上发现血浆中的血浆三唑并通过HPLC-MS分析

Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots

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