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首页> 外文期刊>Journal of applied microbiology >Optimization of cholesterol removal, growth and fermentation patterns of Lactobacillus acidophilus ATCC 4962 in the presence of mannitol, fructo-oligosaccharide and inulin: a response surface methodology approach
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Optimization of cholesterol removal, growth and fermentation patterns of Lactobacillus acidophilus ATCC 4962 in the presence of mannitol, fructo-oligosaccharide and inulin: a response surface methodology approach

机译：在甘露醇，低聚果糖和菊粉存在下优化嗜酸乳杆菌ATCC 4962的胆固醇去除，生长和发酵方式：响应面方法

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Aims: To optimize cholesterol removal by Lactobacillus acidophilus ATCC 4962 in the presence of prebiotics, and study the growth and fermentation patterns of the prebiotics.Methods and Results: Lactobacillus acidophilus ATCC 4962 was screened in the presence of six prebiotics, namely sorbitol, mannitol, maltodextrin, hi-amylose maize, fructo-oligosaccharide (FOS) and inulin in order to determine the best combination for highest level of cholesterol removal. The first-order model showed that the combination of inoculum size, mannitol, FOS and inulin was best for removal of cholesterol. The second-order polynomial regression model estimated the optimum condition of the factors for cholesterol removal by L. acidophilus ATCC 4962 to be 2.64% w/v inoculum size, 4.13% w/v mannitol, 3.29% w/v FOS and 5.81% w/v inulin. Analyses of growth, mean doubling time and short-chain fatty acid (SCFA) production using quadratic models indicated that cholesterol removal and the production of SCFA were growth associated.Conclusions: Optimum cholesterol removal was obtained from the fermentation of L. acidophilus ATCC 4962 in the presence of mannitol, FOS and inulin. Cholesterol removal and the production of SCFA appeared to be growth associated and highly influenced by the prebiotics.Significance and Impact of the Study: Response surface methodology proved reliable in developing the model, optimizing factors and analysing interaction effects. The results provide better understanding on the interactions between probiotic and prebiotics for the removal of cholesterol.
机译：目的：优化在益生元存在下嗜酸乳杆菌ATCC 4962对胆固醇的去除，并研究益生元的生长和发酵方式。方法和结果：在6种益生元（山梨糖醇，甘露醇，麦芽糖糊精，高直链玉米淀粉，低聚果糖（FOS）和菊粉，以便确定去除胆固醇最高水平的最佳组合。一阶模型表明，接种量，甘露醇，FOS和菊粉的组合最适合去除胆固醇。二阶多项式回归模型估计嗜酸乳杆菌ATCC 4962去除胆固醇的最佳条件是接种量为2.64％w / v，甘露醇4.13％w / v，3.29％w / v FOS和5.81％w / v菊粉。使用二次模型分析生长，平均倍增时间和短链脂肪酸（SCFA）的产生，表明胆固醇的去除和SCFA的产生与生长有关。结论：嗜酸乳杆菌ATCC 4962的发酵获得了最佳的胆固醇去除。甘露醇，FOS和菊粉的存在。胆固醇的去除和SCFA的产生似乎与生长有关，并且受益生元的影响很大。研究的意义和影响：响应面法被证明在开发模型，优化因素和分析相互作用效应方面是可靠的。结果提供了对益生菌和益生元之间用于清除胆固醇的相互作用的更好理解。

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