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首页> 外文期刊>Journal of dermatological science >Microarray profiles of human basal cell carcinoma: Insights into tumor growth and behavior.
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Microarray profiles of human basal cell carcinoma: Insights into tumor growth and behavior.

机译：人类基底细胞癌的微阵列概况：洞悉肿瘤的生长和行为。

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PURPOSE:: Basal cell carcinoma (BCC) is the most common human neoplasm. Much interest lies in determining the genetic basis of BCC to explain the unique locally invasive phenotype and infrequent metastatic behavior of these skin tumors. OBJECTIVE:: We sought to examine a gene expression profile for BCC to elucidate new molecules responsible for its unique growth characteristics. METHODS:: We analyzed gene expression patterns of 50 BCC tumors using spotted cDNA microarrays of 1718 characterized human genes related to cancer and immunity. This is the largest and most comprehensive gene expression study ever performed for BCC. Nodular and sclerosing histological subtypes of BCC were examined and compared to normal control skin. After statistical filtering, 374 significantly dysregulated genes were sorted by hierarchical clustering to determine trends of gene expression and similarities between patient gene expression profiles. RESULTS:: A total of 165 upregulated genes and 115 downregulated genes were identified. These covered a range of categories, including extracellular matrix, cell junctions, motility, metastasis, oncogenes, tumor suppressors, DNA repair, cell cycle, immune regulation and angiogenesis. Clusters of genes were either commonly dysregulated across the 50 patient sample, or selectively affected in subsets of tumors. Histological subtypes were not distinguishable by hierarchical clustering. Many of the genes elucidated, including collagen type IV subunits and other novel candidates, possess functions related to extracellular matrix remodeling and metastasis. CONCLUSION:: These results suggest a gene profile which may explain the invasive growth yet rarely metastatic behavior of BCC. The genes identified may also be potential targets for therapeutics aimed at further controlling invasiveness and local destruction of BCC.
机译：目的：基底细胞癌（BCC）是最常见的人类肿瘤。许多兴趣在于确定BCC的遗传基础，以解释这些皮肤肿瘤的独特的局部浸润表型和罕见的转移行为。目的：我们试图检查BCC的基因表达谱，以阐明负责其独特生长特性的新分子。方法：我们使用1718个特征化的与癌症和免疫力相关的人类基因的cDNA微阵列分析了50个BCC肿瘤的基因表达模式。这是有史以来针对BCC进行的最大，最全面的基因表达研究。检查了BCC的结节性和硬化性组织学亚型，并与正常对照皮肤进行了比较。经过统计过滤后，通过层次聚类对374个严重失调的基因进行了分类，以确定基因表达的趋势以及患者基因表达谱之间的相似性。结果：共鉴定到165个上调基因和115个下调基因。这些涵盖了一系列类别，包括细胞外基质，细胞连接，运动性，转移，癌基因，抑癌剂，DNA修复，细胞周期，免疫调节和血管生成。在50个患者样本中，基因簇通常失调，或者在肿瘤子集中有选择地受到影响。组织学亚型不能通过层次聚类加以区分。阐明的许多基因，包括IV型胶原蛋白亚基和其他新的候选物，都具有与细胞外基质重塑和转移有关的功能。结论：这些结果表明基因概况可以解释BCC的侵袭性生长，但很少有转移行为。鉴定出的基因也可能是治疗的潜在靶标，旨在进一步控制BCC的侵袭性和局部破坏。

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