...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of dermatological science >Hair cycle-specific expression of versican in human hair follicles.
【24h】

Hair cycle-specific expression of versican in human hair follicles.

机译：versican在人毛囊中的毛发周期特异性表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Versican, a large chondroitin sulfate proteoglycan molecule, is implicated in the induction of hair morphogenesis, the initiation of hair regeneration, and the maintenance of hair growth in mouse species. In contrast, in human hair follicles, the distribution and the roles of versican remains obscure. OBJECTIVES: To elucidate the implication of versican in normal human hair growth. METHODS: Versican expression was examined by in situ hybridization (mRNA) and immunohistochemistry (protein). RESULTS: The results clearly showed specific versican gene expression in the dermal papilla of anagen, which apparently decreased in the dermal papilla of catagen hair follicles. No specific signal was detectable in telogen hair follicles. Consistent with ISH results, versican immunoreactivity was extended over the dermal papilla of anagen hair follicles, and again, this staining diminished in the catagen phase of human hair follicles. Interestingly, versican proteins were deposited outside K15-positive epithelial cells in the bulge throughout the hair cycle. Versican immunoreactivity in the dermal papilla was almost lost in vellus-like hair follicles affected by male pattern baldness. CONCLUSION: Specific expression of versican in the anagen hair follicles suggests its importance to maintain the normal growing phase of human as well as mouse.
机译：背景：Versican是硫酸软骨素蛋白聚糖的一个大分子，与小鼠毛发的形态发生，毛发再生的开始以及毛发的生长维持有关。相反，在人的毛囊中，versican的分布和作用仍然不清楚。目的：阐明versican对正常人的头发生长的影响。方法：通过原位杂交（mRNA）和免疫组织化学（蛋白质）检测Versican的表达。结果：结果清楚地表明，在毛发生长毛的真皮乳头中有特定的versican基因表达，而在毛发生长的毛囊的真皮乳头中明显降低了。在毛发生长的毛囊中没有检测到特异性信号。与ISH结果一致，versican免疫反应性在生长期毛囊的真皮乳头上扩展，并且再次在人毛囊的催化阶段减少了这种染色。有趣的是，在整个毛发周期中，versican蛋白沉积在凸起中K15阳性上皮细胞外。真皮乳头中的Versican免疫反应性在受男性型秃顶影响的绒毛状毛囊中几乎消失了。结论：Verscan在毛发生长毛囊中的特异性表达表明其在维持人和小鼠的正常生长期中的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号