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首页> 外文期刊>Journal of dermatological science >Prevalence of obesity/adiposity in Japanese psoriasis patients: adiposity is correlated with the severity of psoriasis.
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Prevalence of obesity/adiposity in Japanese psoriasis patients: adiposity is correlated with the severity of psoriasis.

机译：日本牛皮癣患者的肥胖/肥胖症患病率：肥胖症与牛皮癣的严重程度相关。

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摘要

Although epidemiologic survey revealed an association between psoriasis and obesity/adiposity [1 ], no reports are present on the relationship in Japanese psoriasis patients. Obesity induces overproduction of inflammatory cytokines such as tumor necrosis factor a (TNF-alpha), interleukin (IL)-6, and IL-8 in adipose tissue. The serum levels of TNF-alpha, IL-6, and IL-8 are increased in psoriasis and are associated with the disease severity [2]. Adipocytes also produce leptin, which acts primarily through the specific receptors at hypothalamus [3]. Leptin decreases appetite and increases energy expenditure and serum levels of leptin are known to reflect the body fat mass [3]. Adiponectin is another adipocyte-specific secretary protein abundantly present in circulation. Plasma levels of adiponectin are paradoxically decreased in obesity, insulin-resistance [4], and hypoadiponectinemia is closely associated with metabolic syndrome [5]. Recent study demonstrated that adiponectin and TNF-a suppress each other's production and also antagonize each other's function in their target cells [6]. We have shown the increased plasma leptin levels and decreased adiponectin levels in Japanese psoriasis patients [7].
机译：尽管流行病学调查显示牛皮癣与肥胖/肥胖症之间存在关联[1]，但目前尚无有关日本牛皮癣患者关系的报道。肥胖会在脂肪组织中过度产生炎性细胞因子，例如肿瘤坏死因子a（TNF-α），白介素（IL）-6和IL-8。牛皮癣的血清TNF-α，IL-6和IL-8水平升高，并与疾病严重程度相关[2]。脂肪细胞还产生瘦素，瘦素主要通过下丘脑的特定受体起作用[3]。瘦素会降低食欲，增加能量消耗，瘦素的血清水平反映出人体脂肪量[3]。脂联素是在循环中大量存在的另一种脂肪细胞特异性秘书蛋白。肥胖，胰岛素抵抗时血浆脂联素水平反常下降[4]，而脂联素低血症与代谢综合征密切相关[5]。最近的研究表明，脂联素和TNF-α相互抑制对方的生成，并拮抗对方在其靶细胞中的功能[6]。我们已经显示日本牛皮癣患者血浆瘦素水平升高和脂联素水平降低[7]。

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