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首页> 外文期刊>Journal of dermatological science >Increased vagal modulation in atopic dermatitis.
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Increased vagal modulation in atopic dermatitis.

机译：特应性皮炎的迷走神经调节增加。

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BACKGROUND: Atopic dermatitis has been shown to be associated with neurogenic and psychosocial factors. In related atopic diseases such as rhinitis or asthma, a shift in autonomic balance towards a parasympathetic modulation has been described. On the other hand, the psychiatric symptoms known for atopic dermatitis are often associated with decreased vagal modulation. Furthermore, an increased parasympathetic activity has been shown to exhibit anti-inflammatory effects, thus rather alleviating dermatitis symptoms. OBJECTIVE: In order to address these intriguing discrepancies, we aimed to assess the autonomic state in patients suffering from atopic dermatitis. METHODS: Heart rate variability assessment was performed in 30 patients and data were compared to those obtained from matched controls. Furthermore, questionnaires for disease activity and psychosocial stressors were employed. RESULTS: Patients showed higher values for parasympathetic modulation than controls. This was mainly reflected by an increase in the root mean square of successive differences (RMSSD). This parameter further correlated with dermatological symptoms and the time since the last severe exacerbation of the disease. In addition, subgroups of patients with dyshidrosis or photophobia showed significant differences in autonomic modulation under deep respiration. Moreover, cardiac autonomic modulation was hardly altered upon postural change, indicating that autonomic reactivity is only mildly influenced in these patients. CONCLUSION: Patients with atopic dermatitis showed an autonomic dysbalance which is comparable to other diseases related to atopy or allergy. Our findings point to the question whether these alterations are disease-inherent or counter-regulatory, which should be addressed in future studies.
机译：背景：特应性皮炎已被证明与神经源性和社会心理因素有关。在诸如鼻炎或哮喘的相关特应性疾病中，已经描述了自主神经平衡向副交感神经调节的转变。另一方面，特应性皮炎的精神病症状通常与迷走神经调节降低有关。此外，已经显示出增加的副交感活性表现出抗炎作用，从而减轻了皮炎症状。目的：为了解决这些有趣的差异，我们旨在评估特应性皮炎患者的自主神经状态。方法：对30例患者进行了心率变异性评估，并将数据与匹配对照组的数据进行了比较。此外，还使用了针对疾病活动和社会心理压力源的问卷。结果：患者的副交感神经调节值高于对照组。这主要反映在连续差均方根（RMSSD）的增加上。该参数进一步与皮肤病学症状以及自该疾病最后一次严重加重以来的时间相关。此外，运动障碍或畏光患者的亚组在深度呼吸下的自主神经调节表现出显着差异。此外，心脏自主神经调节几乎不会因姿势改变而改变，表明这些患者的自主神经反应性仅受到轻微影响。结论：特应性皮炎患者显示出自主神经失调，可与其他与特应性或过敏相关的疾病相媲美。我们的发现指向这些变化是疾病固有的还是反调控的问题，应在以后的研究中加以解决。

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