Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence.

Sato M; Moriguchi T; Shinozuka K

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Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence.

机译：新的2,2-双（羟甲基）丙酸蒽醌共轭物结合到具有磷酸二酯键的TFO中，有助于与带有嘧啶缺口的聚嘌呤序列的dsDNA形成三链体。

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An anthraquinone derivative conjugated with 2,2-bis(hydroxymethyl)propionic acid as a novel non-nucleosidic component was synthesized and successfully incorporated into an internal region of 14-mer triplex-forming oligonucleotide (TFO) via the phosphoramidite method. The resulted novel TFO exhibits remarkable enhancement effect on the thermal stability of a DNA triplex upon binding to a pyrimidine-gap containing polyprurine sequence.

机译：合成了与2,2-双（羟甲基）丙酸共轭的蒽醌衍生物作为新型非核苷成分，并通过亚磷酰胺方法成功地将其掺入14-mer三链体形成寡核苷酸（TFO）的内部区域。所产生的新型TFO在结合到含嘧啶间隙的多尿素序列上对DNA三链体的热稳定性表现出显着的增强作用。

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《Bioorganic and Medicinal Chemistry Letters》 |2004年第5期|共4页
作者
Sato M; Moriguchi T; Shinozuka K;
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正文语种 eng
中图分类基础医学;
关键词
Propionic acid; pyrimidine; novel; phosphodiester; Bears; 熊;

机译：丙酸;嘧啶;新颖;磷酸二酯;熊;熊;

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1. Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence. [J] . Sato M, Moriguchi T, Shinozuka K Bioorganic and Medicinal Chemistry Letters . 2004,第5期

机译：新的2,2-双（羟甲基）丙酸蒽醌共轭物结合到具有磷酸二酯键的TFO中，有助于与带有嘧啶缺口的聚嘌呤序列的dsDNA形成三链体。
2. Determination of Highly Polar Compounds In Reaction Mixtures Of 2,2-Bis(Hydroxymethyl)Propionic Acid And 3-Hydroxy-2,2-Bis(Hydroxymethyl)Propionic Acid By HPLC [J] . Eija Koivusalmi, Jukka Tulisalo Journal of liquid chromatography and related technologies . 2001,第2期

机译：高效液相色谱法测定2,2-双（羟甲基）丙酸与3-羟基-2,2-双（羟甲基）丙酸反应混合物中的高极性化合物
3. Selective monobenzylation of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) to yield an AB linear monomer and analogous linear oligomers [J] . Giesen Joseph A., Grayson Scott M. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2020,第25期

机译：2,2-双（羟甲基）丙酸（BIS-MPa）的选择性单偏移，得到AB线性单体和类似的线性低聚物
4. Effect of 2,2-Bis(Hydroxymethyl) Propionic Acid Content on the Properties of Aqueous Polyurethane [C] . Nan Song, Xiulan Xin, Bin Li China academic conference on printing and packaging . 2019

机译：2,2-双（羟甲基）丙酸含量对水性聚氨酯水性性质的影响
5. ELECTROFLOTATION OF 2,2-BIS (HYDROXYMETHYL) PROPIONIC ACID FROM AQUEOUS SYSTEMS [O] . Larisa Mocanu, Maria Gonta, Vera Mateevici, 2018

机译：来自水性体系的2,2-双（羟甲基）丙酸的电滤护

Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence.

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