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首页> 外文期刊>Journal of dermatological science >Classification of inflammatory skin diseases: A proposal based on the disorders of the three-layered defense systems, barrier, innate immunity and acquired immunity
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Classification of inflammatory skin diseases: A proposal based on the disorders of the three-layered defense systems, barrier, innate immunity and acquired immunity

机译：炎性皮肤疾病的分类：基于三层防御系统疾病，屏障，先天免疫和获得性免疫的建议

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摘要

The host defense system of the skin is composed of (1) a barrier, (2) innate immunity, and (3) acquired immunity. Inflammatory skin diseases can be classified into one of the disorders of these layers of the defense system, unless there is an ordinary response to specific infectious agents or internal/external injury. Any inflammatory skin disease partly simulates the response to real infections or dangers. Disorders of acquired immunity can be classified into (1) immunodeficiency, (2) immunohyperactivity (allergy), and (3) qualitative disorder (autoimmunity). Disorders of innate immunity can be classified into (1) innate immunodeficiency, (2) innate immunohyperactivity (general or local autoinflammation), and (3) qualitative disorder (general or local innate autoimmunity). The barrier of the skin is composed of (1) the physical barrier and (2) the chemical barrier. Several diseases, such as atopic dermatitis, are attributed to the disorder of these components of the barrier. Here, we propose an algorithm to classify the pathology of inflammatory skin diseases by means of what disorder in the specific layer of the host defense system is truly responsible. (C) 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
机译：皮肤的宿主防御系统由（1）屏障，（2）先天免疫和（3）获得性免疫组成。炎症性皮肤病可以分类为防御系统这些层的疾病之一，除非对特定的传染性病原体或内部/外部损伤有普通反应。任何炎症性皮肤病都会部分模拟对真实感染或危险的反应。获得性免疫的疾病可分为（1）免疫缺陷，（2）免疫机能亢进（过敏）和（3）定性疾病（自身免疫）。先天性免疫疾病可分为（1）先天性免疫缺陷，（2）先天性免疫功能亢进（一般或局部自身炎症）和（3）定性疾病（一般或局部先天性自身免疫）。皮肤的屏障由（1）物理屏障和（2）化学屏障组成。几种疾病，如特应性皮炎，归因于屏障中这些成分的紊乱。在这里，我们提出了一种算法，可以根据宿主防御系统特定层中的哪些疾病真正造成疾病来对炎症性皮肤病的病理进行分类。 （C）2014年日本皮肤病研究学会。由Elsevier Ireland Ltd.发布。保留所有权利。

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