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首页> 外文期刊>Journal of dermatological science >Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers
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Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers

机译：慢性下肢静脉溃疡中人中性粒细胞α-防御素水平升高

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摘要

Chronic venous leg ulcers (CVLU) are characterized by bacterial colonisation, ongoing and unregulated inflammation and excessive proteolysis, chemotacticactivity and endothelial leakage. Initial pathogeneticsteps involve activation of endothelial cells and extravasation of inflammatory cells into the wound area. The high influx of leukocytes and subsequent release of proteases from polymorphonuclearneutrophils (PMN) leads to high proteolysis in the surroundings of chronic ulcers. These findings, together with the observation that keratinocytes display a non-migratory phenotype in CVLU leads to a failure of re-epithelialization (for review see ). PMNs contain various antimicrobial peptides and proteins involved in innate defence against invading microbes. One significant group, the defensinslocated in azurophil granules, are secreted into the phagolysosome following phagocytosis of bacteria. However, upon stimulation with potent stimuli, defensins may also be released extracellularly from PMNs . Recent findings indicate that defensins may exert functions beyond antimicrobial activity, being involved in chemotaxis and activation of antigens-presenting cells, thus belonging to the group of "alarmins" involved in various aspects of antimicrobial defence .
机译：慢性静脉曲张性溃疡（CVLU）的特征是细菌定植，持续和不受控制的炎症以及过度的蛋白水解，趋化活性和内皮渗漏。最初的致病步骤涉及内皮细胞的活化和炎性细胞渗入伤口区域。白细胞的大量流入以及随后从多形核中性粒细胞（PMN）中释放的蛋白酶导致慢性溃疡周围环境中的高蛋白水解。这些发现以及对角质形成细胞在CVLU中显示出非迁移表型的观察结果导致重新上皮化失败（有关综述，请参见）。 PMN包含与先天防御入侵微生物有关的各种抗菌肽和蛋白质。细菌吞噬作用后，一组重要的防御素（位于防御固氮颗粒中）被分泌到吞噬溶酶体中。但是，在用强力刺激刺激后，防御素也可能从PMNs释放到细胞外。最近的发现表明防御素可能发挥超出抗菌活性的功能，参与抗原呈递细胞的趋化性和活化，因此属于参与抗菌防御的各个方面的“ alarmins”组。

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