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首页> 外文期刊>Journal of dentistry >The development and validation of a new technology, based upon 1.5% arginine, an insoluble calcium compound and fluoride, for everyday use in the prevention and treatment of dental caries
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The development and validation of a new technology, based upon 1.5% arginine, an insoluble calcium compound and fluoride, for everyday use in the prevention and treatment of dental caries

机译：基于1.5％的精氨酸，不溶性钙化合物和氟化物的新技术的开发和验证，可用于日常预防和治疗龋齿

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Objective: This paper briefly discusses caries prevalence, the multi-factorial nature of caries etiology, caries risk and the role and efficacy of fluoride. The paper also highlights research on bacterial metabolism which provided understanding of the mouth's natural defenses against caries and the basis for the development of a new technology for the everyday prevention and treatment of caries. Finally, evidence that the technology complements and enhances the anti-caries efficacy of fluoride toothpaste is summarized. Conclusions: Global data show that dental caries is a prevalent disease, despite the successful introduction of fluoride. Caries experience depends on the balance between consumption of sugars and oral hygiene and the use of fluoride. Three scientific concepts are fundamental to new measures to detect, treat and monitor caries: (1) dental caries is a dynamic process, (2) dental caries is a continuum of stages from reversible, pre-clinical to irreversible, clinically detectable lesions, and (3) the caries process is a balance of pathological and protective factors that can be modulated to manage caries. Fluoride functions as a protective factor by arresting and reversing the caries process, but fluoride does not prevent pathological factors that initiate the process. A novel technology, based upon arginine and an insoluble calcium compound, has been identified which targets dental plaque to prevent initiation of the caries process by reducing pathological factors. As the mechanisms of action of arginine and fluoride are highly complementary, a new dentifrice, which combines arginine with fluoride, has been developed and clinically proven to provide superior caries prevention.
机译：目的：本文简要讨论龋齿的患病率，龋齿病因的多因素性质，龋齿风险以及氟化物的作用和功效。本文还重点介绍了细菌代谢的研究，该研究提供了对口腔天然抵抗龋齿的防御作用的理解，并为开发日常预防和治疗龋齿的新技术奠定了基础。最后，总结了该技术补充并增强了氟化物牙膏的抗龋效果的证据。结论：全球数据显示，尽管成功引入了氟化物，但龋齿仍是一种普遍的疾病。龋病的经验取决于食糖和口腔卫生与使用氟化物之间的平衡。三个科学概念是检测，治疗和监测龋齿的新措施的基础：（1）龋齿是一个动态过程，（2）龋齿是从可逆，临床前到不可逆的临床可检测病变的连续过程，以及（3）龋齿过程是可以调节以控制龋齿的病理和保护因素之间的平衡。氟化物通过阻止和逆转龋齿过程而起到保护作用，但是氟化物不能阻止引发该过程的病理因素。已经确定了一种基于精氨酸和不溶性钙化合物的新技术，该技术以牙菌斑为靶标，通过减少病理因素来防止龋齿的发生。由于精氨酸和氟化物的作用机理高度互补，因此开发了一种将精氨酸和氟化物结合的新型洁牙剂，并在临床上证明其可提供出色的龋齿预防功能。

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