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首页> 外文期刊>Journal of dermatological science >Relationship between cutaneous barrier function and ceramide species in human stratum corneum.
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Relationship between cutaneous barrier function and ceramide species in human stratum corneum.

机译:人角质层中皮肤屏障功能与神经酰胺种类的关系。

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摘要

Ceramides constitute a major lipid class in stratum corneum (SC), playing important roles in cutaneous barrier function (CBF) and pathophysiology of skin disorders with barrier disruption [1-3]. Ceramide is a family of lipid molecules composed of a sphingoid base: dihydrosphingosine, sphingosine, phytosphingo-sine or 6-hydroxysphingosine is amide-linked to nonhydroxy fatty acid, alpha-hydroxy fatty acid or ester-linked epsilon-hydroxy fatty acid. The combination of 4 sphingoid bases and 3 fatty acid species can generate 12 possible ceramide classes and more diverse species due to their variable fatty acid chain length. Recently, Masukawa et al. reported that 342 species, 10 classes ceramide exist in human SC [4,5], contributing towards the lipidomics in skin biology research.
机译:神经酰胺构成角质层(SC)中的主要脂质类别,在皮肤屏障功能(CBF)和具有屏障破坏作用的皮肤疾病的病理生理中发挥重要作用[1-3]。神经酰胺是由鞘氨醇碱基组成的脂质分子家族:二氢鞘氨醇,鞘氨醇,植物鞘氨醇或6-羟基鞘氨醇酰胺键合至非羟基脂肪酸,α-羟基脂肪酸或酯键合的ε-羟基脂肪酸。 4种鞘氨醇碱基和3种脂肪酸种类的组合,由于其可变的脂肪酸链长,可产生12种可能的神经酰胺类和更多种。最近,Masukawa等人。据报道,人类SC中存在342种10类神经酰胺[4,5],有助于皮肤生物学研究中的脂质组学。

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