...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of dermatological science >Expression of S100 protein family members in normal skin and sweat gland tumors
【24h】

Expression of S100 protein family members in normal skin and sweat gland tumors

机译：S100蛋白家族成员在正常皮肤和汗腺肿瘤中的表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Despite our growing knowledge regarding the biology of S100 family proteins in cancers and internal diseases, limited data are available with their distribution in normal skin and in sweat gland tumors. Objective: To study the expression and distribution pattern of multiple S100 proteins in normal skin and in the tumors of sweat glands. Methods: Immunohistological staining was performed using S100A2, S100A4, S100A6, S100A7, S100A8/9, S100A11, and S100P in 41 cases of various kinds of sweat gland tumors and in 13 cases of normal skin. Results: In normal skin, S100A2, S100A6, S100A7, and S100P staining were observed in the sweat glands. S100A2 positively stained in the outer layer of the eccrine duct. S100A6 immunolabeling was observed in the secretory portion of the eccrine gland. Myoepithelial cells of the apocrine gland were positive for S100A2 and S100A6. S100A7 was positive in the acrosyringium, ductal, and secretory portions of the eccrine gland and in the inner layer of the apocrine gland. Intense S100P staining was detected in the inner layer of the acrosyringium and eccrine ducts. Langerhans cells and melanocytes showed strong immunoreactivity to S100A4. Extramammary Paget's disease (EMPD) expressed S100A7 and S100P with partial S100A6 and S1004 staining. Eccrine poroma expressed S100A2 and S100A7 with partial labeling with S100A6. Syringoma expressed S100A2, S1007, and S100P. Apocrine hidrocystoma expressed S100A2 with partial S100A6 and S100A7 immunoreactivity. Syringocystadenoma papilliferum expressed S100A2, S100A6, S100A7, and S100P. Conclusion: S100A2, S100A6, S100A7, and S100P proteins are specifically involved in structure-related distribution and are potentially useful for differential diagnoses of sweat gland tumors.
机译：背景：尽管我们对S100家族蛋白在癌症和内科疾病中的生物学了解越来越多，但有关其在正常皮肤和汗腺肿瘤中分布的数据仍然有限。目的：研究多种S100蛋白在正常皮肤和汗腺肿瘤中的表达和分布规律。方法：在41例各种汗腺肿瘤和13例正常皮肤中，使用S100A2，S100A4，S100A6，S100A7，S100A8 / 9，S100A11和S100P进行免疫组织学染色。结果：在正常皮肤中，汗腺中观察到S100A2，S100A6，S100A7和S100P染色。 S100A2在内分泌管外层呈阳性染色。在外分泌腺的分泌部分观察到S100A6免疫标记。顶泌腺的肌上皮细胞对S100A2和S100A6呈阳性。 S100A7在外分泌腺的顶动脉，导管和分泌部分以及顶分泌腺的内层呈阳性。在Acrosyringium和内分泌管的内层检测到强烈的S100P染色。朗格汉斯细胞和黑色素细胞显示出对S100A4的强免疫反应性。乳腺佩吉特氏病（EMPD）表达了S100A7和S100P，并具有部分S100A6和S1004染色。内分泌性孔瘤表达S100A2和S100A7，并带有S100A6的部分标记。 Syringoma表达S100A2，S1007和S100P。顶泌性胆囊瘤表达具有部分S100A6和S100A7免疫反应性的S100A2。乳头状膀胱囊腺瘤表达了S100A2，S100A6，S100A7和S100P。结论：S100A2，S100A6，S100A7和S100P蛋白与结构相关的分布特别相关，并可能对汗腺肿瘤的鉴别诊断有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号