...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of dermatological science >Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis
【24h】

Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis

机译：S100A6和基质金属蛋白酶9异常表达，但S100A2，S100A4和S100A7异常表达与表皮癌变有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: S100 proteins belong to a family of calcium-binding proteins that regulate cell proliferation and differentiation. Despite our growing knowledge about the biology of S100 proteins in some human cancers, little is known about the expression of S100 family members in epidermal tumors and their clinical significance. Objective: To determine the expression of S100A2, S100A4, S100A6, S100A7, as well as matrix metalloproteinases 9 (MMP9) in a spectrum of epidermal tumors with benign and malignant characteristics. Methods: Immunohistological staining was performed for S100A2, S100A4, S100A6, S100A7, and MMP9 in 101 cases of various types of epidermal tumors, viz., squamous cell carcinoma (SCC), Bowen's disease (BD), actinic keratosis (AK), basal cell carcinoma (BCC), keratoacanthoma (KA), and seborrheic keratosis (SK). Thirteen specimens of normal skin (NS) served as control. Results: S100A2, S100A6, and S100A7 positive immunostaining was variably observed in different epidermal tumors. S100A4 staining was not observed in any epidermal tumors, but was clearly visible in dendritic cells. MMP9 immunostaining was positive only in 22/26 (84.62%) of SCC and 2/15 (13.33%) of BD cases. Expression of S100A2, S100A6, and S100A7 was increased in tumor cells compared to NS. However, only S100A6 expression was significantly associated with malignant transformation of epidermal tumors. Moreover, S100A6 expression was correlated with MMP9 expression in metastatic SCC. Conclusions: Epidermal tumors show increased expression of S100A2 and S100A7 proteins. S100A4 may be a useful and distinct marker for epidermal dendritic cells. Expression of S100A6 and MMP9 in combination is associated with the development of SCC.
机译：背景：S100蛋白属于调节细胞增殖和分化的钙结合蛋白家族。尽管我们对某些人类癌症中S100蛋白的生物学知识日益了解，但对S100家族成员在表皮肿瘤中的表达及其临床意义知之甚少。目的：确定S100A2，S100A4，S100A6，S100A7以及基质金属蛋白酶9（MMP9）在一系列具有良性和恶性特征的表皮肿瘤中的表达。方法：对101例各种类型的表皮肿瘤，即鳞状细胞癌（SCC），鲍恩氏病（BD），光化性角化病（AK），基底细胞的S100A2，S100A4，S100A6，S100A7和MMP9进行免疫组织学染色细胞癌（BCC），角化棘皮瘤（KA）和脂溢性角化病（SK）。十三个正常皮肤（NS）标本作为对照。结果：在不同的表皮肿瘤中观察到S100A2，S100A6和S100A7阳性免疫染色的变化。在任何表皮肿瘤中均未观察到S100A4染色，但在树突状细胞中清晰可见。 MMP9免疫染色仅在22/26（84.62％）的SCC和2/15（13.33％）的BD阳性。与NS相比，肿瘤细胞中S100A2，S100A6和S100A7的表达增加。然而，仅S100A6表达与表皮肿瘤的恶性转化显着相关。此外，在转移性SCC中，S100A6表达与MMP9表达相关。结论：表皮肿瘤显示S100A2和S100A7蛋白表达增加。 S100A4可能是表皮树突状细胞的有用且独特的标记。 S100A6和MMP9的联合表达与SCC的发展有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号