Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study

Scheuer Cecilie; Pommergaard Hans-Christian; Rosenberg Jacob; Gogenur Ismail

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Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study

机译：局部褪黑激素剂量依赖性的防晒作用：一项随机，安慰剂对照，双盲研究

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Background: Ultraviolet radiation (UVR) by sul - l>nlight results in an increasing number of skin conditions. Earlier studies have suggested a protective effect of topical treatment with the pineal hormone melatonin. However, this protective effect has never been evaluated in natural sunlight, and the optimal dosing has not been clarified.

机译：背景：紫外线的紫外线（UVR）导致皮肤状况增加。较早的研究表明，用松果激素褪黑激素进行局部治疗具有保护作用。然而，这种保护作用从未在自然日光下进行评估，并且尚未阐明最佳剂量。

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《Journal of dermatological science》 |2016年第2期|共8页
作者
Scheuer Cecilie; Pommergaard Hans-Christian; Rosenberg Jacob; Gogenur Ismail;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
Topical melatonin; Non-melanoma skincancer; Natural sun exposure;

机译：局部褪黑激素;非黑色素瘤皮肤癌;自然日晒;

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1. Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study [J] . Scheuer Cecilie, Pommergaard Hans-Christian, Rosenberg Jacob, Journal of dermatological science . 2016,第2期

机译：局部褪黑激素剂量依赖性的防晒作用：一项随机，安慰剂对照，双盲研究
2. A randomized, double-blind, placebo-controlled, dose-escalation first-in-man study (phase 0) to assess the safety and efficacy of topical cytosolic phospholipase A2 inhibitor, AVX001, in patients with mild to moderate plaque psoriasis [J] . Omland S. H., Habicht A., Damsbo P., Journal of the European Academy of Dermatology and Venereology: JEADV . 2017,第7期

机译：随机，双盲，安慰剂控制，剂量升级第一in-man学习（第0阶段），以评估局部细胞质磷脂酶A2抑制剂，AVX001的安全性和功效，以温和至中度斑块牛皮癣患者
3. Efficacy of topical 1% lidocaine in the symptomatic treatment of pain associated with oral mucosal trauma or minor oral aphthous ulcer: a randomized, double-blind, placebo-controlled, parallel-group, single-dose study. [J] . Descroix V, Coudert AE, Vige A, Journal of orofacial pain. . 2011,第4期

机译：外用1％利多卡因对症治疗与口腔粘膜创伤或轻度口腔口疮相关的疼痛的功效：一项随机，双盲，安慰剂对照，平行组，单剂量研究。
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A Phase 1B, Double-blind, Placebo-controlled, Parallel-group, Multi-dose Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis and Fecal Fat in Subjects with Functional Constipation [D] . Oduyebo, Ibironke. 2018

机译：1B，双盲，安慰剂控制，并行组，NGM282对结肠转运，胆汁酸痛和患者功能性便秘的粪便脂肪的药物动力学的多剂量研究
6. A pilot double-blind randomised placebo-controlled dose–response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol [O] . Shavi Fernando, Tiki Osianlis, Beverley Vollenhoven, 2014

机译：一项试验性双盲随机安慰剂对照剂量反应试验评估褪黑激素对不育症治疗（MIART）的影响：研究方案
7. A pilot double-blind randomised placebo-controlled dose-response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol [O] . S. Fernando, T. Osianlis, B. Vollenhoven, 2014

机译：试点双盲随机安慰剂对照剂量 - 反应试验评估褪黑素对不孕症治疗（MIART）的影响：研究方案

Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study

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