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首页> 外文期刊>Journal of dermatological science >Tolerogenic dendritic cells and regulatory T cells: a two-way relationship.
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Tolerogenic dendritic cells and regulatory T cells: a two-way relationship.

机译：致耐受性树突状细胞和调节性T细胞：双向关系。

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摘要

At first glance, dendritic cells (DCs) and regulatory T cells (Tregs) do not have much in common. DCs are characterized by their unsurpassed T cell stimulatory capacity, whereas Tregs are marked by the ability to suppress proliferation of effector T cells. However, only mature/activated DCs stimulate T cell proliferation, whereas immature DCs induce Tregs. This provides a means by which peripheral tolerance is maintained: in the absence of inflammation and disease, DCs encounter apoptotic cells and "self" detritus in peripheral tissues. Thus, DCs constantly sample the peripheral environment and, accordingly, the presentation of "self" by these steady state DCs results in induction of suppressive Tregs. Vice versa, Tregs are able to affect DC development, preventing maturation and inducing IL-10, as well as immunosuppressive molecules of the B7-H family, in DCs. Therefore, these novel findings establish a mutual interaction between DCs and Tregs for the upkeep of immunosuppression: immature DCs induce Tregs and inversely Tregs prepare DCs to become immunosuppressive, thereby extending the immunosuppressive function of Tregs. The possible means of cellular interactions as well as the consequences for tolerance and immunity are discussed in this review.
机译：乍一看，树突状细胞（DCs）和调节性T细胞（Tregs）没有太多共同之处。 DC的特点是其无与伦比的T细胞刺激能力，而Tregs则具有抑制效应T细胞增殖的能力。但是，只有成熟/激活的DC刺激T细胞增殖，而未成熟的DC诱导Treg。这提供了维持外周耐受性的方法：在没有炎症和疾病的情况下，DC在外周组织中遇到凋亡细胞和“自身”碎屑。因此，DC不断采样外围环境，因此，这些稳态DC呈现“自我”会导致产生抑制性Treg。反之亦然，Tregs能够影响DC的DC发育，防止其成熟并诱导IL-10以及B7-H家族的免疫抑制分子。因此，这些新发现建立了DC和Treg之间的相互作用，以维持免疫抑制：未成熟的DC诱导Treg，而Treg则使DC变得免疫抑制，从而扩展了Treg的免疫抑制功能。在这篇综述中讨论了细胞相互作用的可能方式以及对耐受性和免疫性的影响。

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