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首页> 外文期刊>Journal of dermatological science >Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells.
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Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells.

机译：树突状细胞作为抗原特异性Foxp3 +调节性T细胞的控制器。

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摘要

Regulatory T cells (Treg) are a subpopulation of CD4(+) lymphocytes that maintain immunological self-tolerance in the periphery. Treg also regulate or suppress other classes of immune response such as allograft rejection, allergy, tumor immunity, and responses to microbes. Treg express the Foxp3 transcription factor and CD25, the high affinity interleukin-2 receptor (IL-2R). Treg are divided into two types: naturally occurring Treg derived from thymus (natural Treg) and Treg induced from Foxp3(-) CD4(+) T cells in the periphery (induced Treg). It would be valuable to understand how to control the generation of antigen-specific Treg, which could also provide a new approach to treat autoimmunity, allergy or allograft rejection without suppressing immune responses to tumor and microbes. In this review, we will discuss the role of dendritic cells (DCs) in controlling antigen-specific natural Treg and induced Treg. Natural Treg are anergic upon T cell receptor stimulation generally, however, we found that the antigen-specific natural Treg can be expanded by antigen-presenting mature bone marrow-derived dendritic cells (BM-DCs). Furthermore, recent studies showed that antigen-specific Treg can be induced from Foxp3(-) CD25(-) CD4(+) T cells by antigen-presenting DCs, particularly select subsets of DCs in the periphery. These findings need to be pursued to develop novel immune suppressive therapies using antigen-specific Treg educated by DCs.
机译：调节性T细胞（Treg）是CD4（+）淋巴细胞的一个亚群，在外周维持免疫自耐受性。 Treg还调节或抑制其他类型的免疫反应，例如同种异体移植排斥，变态反应，肿瘤免疫和对微生物的反应。 Treg表达Foxp3转录因子和CD25，即高亲和力白介素2受体（IL-2R）。 Treg分为两种类型：源自胸腺的天然Treg（天然Treg）和由周边的Foxp3（-）CD4（+）T细胞诱导的Treg（诱导的Treg）。了解如何控制抗原特异性Treg的产生将是有价值的，这也可以提供一种新的方法来治疗自身免疫，变态反应或同种异体移植排斥而不抑制对肿瘤和微生物的免疫反应。在这篇综述中，我们将讨论树突状细胞（DCs）在控制抗原特异性天然Treg和诱导Treg中的作用。天然Treg通常对T细胞受体刺激无反应，但是，我们发现抗原特异性天然Treg可通过呈递抗原的成熟骨髓衍生树突状细胞（BM-DC）进行扩增。此外，最近的研究表明，可以通过抗原呈递DC，特别是外围DC的特定子集，从Foxp3（-）CD25（-）CD4（+）T细胞诱导抗原特异性Treg。需要使用这些发现来开发新的免疫抑制疗法，使用由DC诱导的抗原特异性Treg。

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