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首页> 外文期刊>Journal of dermatological science >Treatment with IFN-gamma increases serum levels of Th1 chemokines and decreases those of Th2 chemokines in patients with mycosis fungoides.
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Treatment with IFN-gamma increases serum levels of Th1 chemokines and decreases those of Th2 chemokines in patients with mycosis fungoides.

机译：真菌性真菌病患者使用IFN-γ治疗可增加Th1趋化因子的血清水平，并降低Th2趋化因子的血清水平。

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BACKGROUND: Interferon-gamma (IFN-gamma) is used for the treatment of mycosis fungoides, which is a Th2 neoplasm with elevation of serum Th2 chemokines. Although therapeutic effectiveness of IFN-gamma is caused at least partly by augmented activity of cytotoxic T cells against the tumor cells, its modulation on chemokine production remains unknown. OBJECTIVE: Alterations in the serum levels of Th1 chemokines, IP-10 and MIG, and Th2 chemokines, TARC and MDC, were examined in mycosis fungoides patients treated with recombinant IFN-gamma. METHODS: Four patients with mycosis fungoides received intravenous injections of IFN-gamma for 14 or 28 days. On day 0, 7, 14, and 28, sera were obtained from the patients, and the concentrations of TARC, MDC, IP-10, and MIG were measured by ELISA, along with the percentages of peripheral blood Th1 and Th2 cells. RESULTS: Whereas the levels of TARC and MDC were decreased by IFN-gamma treatment, those of IP-10 and MIG were increased. In particular, the increment of MIG was remarkable. No substantial change of Th1 or Th2 cell number was observed. CONCLUSION: In IFN-gamma treatment as well as other therapies, TARC may serve as a marker for the disease activity of mycosis fungoides. The dramatic elevation of MIG by IFN-gamma suggests the strong dependency of MIG production on IFN-gamma and the participation of MIG in skin-infiltration of tumoricidal cytotoxic T cells.
机译：背景：干扰素-γ（IFN-γ）用于治疗真菌病，这是一种Th2肿瘤，其血清Th2趋化因子升高。尽管IFN-γ的治疗效果至少部分是由细胞毒性T细胞对肿瘤细胞的增强活性引起的，但是其对趋化因子产生的调节仍然未知。目的：检测用重组IFN-γ治疗的真菌病患者的Th1趋化因子，IP-10和MIG以及Th2趋化因子，TARC和MDC的血清水平变化。方法：4名真菌病真菌病患者接受了IFN-γ的静脉注射，持续14或28天。在第0、7、14和28天，从患者获得血清，并通过ELISA测量TARC，MDC，IP-10和MIG的浓度以及外周血Th1和Th2细胞的百分比。结果：尽管IFN-γ治疗降低了TARC和MDC的水平，但增加了IP-10和MIG的水平。特别是，MIG的增长非常显着。没有观察到Th1或Th2细胞数量的实质性变化。结论：在IFN-γ治疗及其他疗法中，TARC可作为蕈样真菌病疾病活性的标志物。 IFN-γ引起的MIG急剧升高表明MIG产生对IFN-γ的强烈依赖性以及MIG参与杀伤性细胞毒性T细胞的皮肤浸润。

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