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Staphylococcus aureus in relation to physical, physiological and subjective conditions of apparently normal human skin.

机译:金黄色葡萄球菌与明显正常的人皮肤的生理,生理和主观状况有关。

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摘要

Staphylococci are facultative anaerobic, Gram-positive bacteria that cause infections in humans and various animal species [1]. Staphylococcus aureus is an opportunistic pathogen responsible for a broad range of infections in human such as food poisoning and pneumonia [2]. It is frequently found on human skin and known as a commensal organism [3]. It secretes several toxins and enzymes which are associated with a variety of cutaneous and systemic diseases such as atopic dermatitis (AD), impetigo, furuncle, subcutaneous abscess, staphylococcal scalded skin syndrome and toxic shock syndrome [4]. It can colonize the tissues when protective systems are breached, such as in AD patients having low immunity and an impaired skin barrier. Under such conditions, a vicious circle may ensue: S. aureus colonize the lesions [5] and secret toxins and/or enzymes that induce itching and disrupt the skin barrier. Attempts have been made for controlling the balance of skin microflora to improve AD [5].
机译:葡萄球菌是兼性厌氧,革兰氏阳性细菌,可引起人类和各种动物的感染[1]。金黄色葡萄球菌是一种机会病原体,可引起人类广泛的感染,如食物中毒和肺炎[2]。它经常在人的皮肤上发现,被称为共生生物[3]。它分泌几种毒素和酶,这些毒素和酶与多种皮肤和全身性疾病有关,例如特应性皮炎(AD),脓疱病,fur,皮下脓肿,葡萄球菌烫伤皮肤综合症和中毒性休克综合症[4]。当保护系统被破坏时,例如免疫力低下和皮肤屏障受损的AD患者,它可以在组织中定植。在这种情况下,可能会形成恶性循环:金黄色葡萄球菌定植在病灶处[5],以及引起瘙痒并破坏皮肤屏障的秘密毒素和/或酶。已经尝试控制皮肤菌群的平衡以改善AD [5]。

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