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首页> 外文期刊>Journal of dermatological science >Histamine modulates the responsiveness of keratinocytes to IL-17 and TNF-alpha through the H1-receptor.
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Histamine modulates the responsiveness of keratinocytes to IL-17 and TNF-alpha through the H1-receptor.

机译：组胺通过H1受体调节角质形成细胞对IL-17和TNF-α的反应性。

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摘要

Interleukin (IL)-17-producing CD4+ helper T cells, TM7 cells, are involved in protection against bacterial pathogens and in the pathogenesis of various cutaneous inflammatory diseases, such as psoriasis and contact hypersensitivity [1]. In addition, a higher percentage of Thl7 cells has been detected in the lesional skin and in the peripheral blood in the acute exacerbation phase of atopic dermatitis (AD), compared to normal controls [2,3]. It has been thought that IL-17 produced by TM7 cells infiltrating into the dermis acts on keratinocytes to produce inflammatory mediators, such as IL-8 and granulocyte macrophage colony-stimulating factor (GM-CSF) to chemoattract neutrophils and T cells and to activate Langerhans cells and endothelial cells, respectively [2,4], which initiates and enhances cutaneous inflammations.
机译：产生白介素（IL）-17的CD4 +辅助性T细胞TM7细胞参与针对细菌病原体的保护以及各种皮肤炎性疾病（如牛皮癣和接触性超敏反应）的发病机理[1]。此外，与正常对照组相比，在特应性皮炎（AD）急性加重期的病变皮肤和外周血中检测到更高百分比的Thl7细胞[2,3]。已经认为，由TM7细胞渗透到真皮中产生的IL-17作用于角质形成细胞以产生炎性介质，例如IL-8和粒细胞巨噬细胞集落刺激因子（GM-CSF），以化学吸引中性粒细胞和T细胞并活化。朗格汉斯细胞和内皮细胞分别[2,4]，它们引发并增强皮肤炎症。

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