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首页> 外文期刊>Journal of dermatological science >Galectin-3 and the skin.
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Galectin-3 and the skin.

机译：Galectin-3和皮肤。

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摘要

Galectin-3 is highly expressed in epithelial cells including keratinocytes and is involved in the pathogenesis of inflammatory skin diseases by affecting the functions of immune cells. For example, galectin-3 can contribute to atopic dermatitis (AD) by promoting polarization toward a Th2 immune response by regulating dendritic cell (DC) and T cell functions. In addition, galectin-3 may be involved in the development of contact hypersensitivity by regulating the migratory capacity of antigen presenting cells. Galectin-3 may act as a regulator of epithelial tumor progression and development through various signaling pathways, such as inhibiting keratinocyte apoptosis through regulation of the activation status of extracellular signal-regulated kinase (ERK) and activated protein kinase B (AKT). Galectin-3 is detected at different stages of melanoma development. In contrast, a marked decrease in the expression of galectin-3 is observed in non-melanoma skin cancers, such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Galectin-3 may play an important role in tumor cell growth, apoptosis, cell motility, invasion, and metastasis. Galectin-3 may be a novel therapeutic target for a variety of skin diseases.
机译：Galectin-3在包括角质形成细胞在内的上皮细胞中高度表达，并通过影响免疫细胞的功能而参与炎症性皮肤病的发病机理。例如，galectin-3可通过调节树突状细胞（DC）和T细胞功能，促进向Th2免疫应答的极化，从而促进特应性皮炎（AD）。另外，半乳凝素-3可通过调节抗原呈递细胞的迁移能力而参与接触性超敏反应的发展。 Galectin-3可能通过各种信号通路，例如通过调节细胞外信号调节激酶（ERK）和活化蛋白激酶B（AKT）的激活状态抑制角质形成细胞凋亡，来充当上皮肿瘤进展和发展的调节剂。在黑色素瘤发展的不同阶段检测到Galectin-3。相反，在非黑色素瘤皮肤癌如鳞状细胞癌（SCC）和基底细胞癌（BCC）中观察到galectin-3表达的显着降低。 Galectin-3可能在肿瘤细胞的生长，凋亡，细胞运动，侵袭和转移中起重要作用。 Galectin-3可能是多种皮肤疾病的新型治疗靶标。

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