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首页> 外文期刊>Journal of dermatological science >Arginine metabolism in soft tissue sarcoma.
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Arginine metabolism in soft tissue sarcoma.

机译：软组织肉瘤中的精氨酸代谢。

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BACKGROUND: L-Arginine (L-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes. Whether L-Arg metabolism has detrimental or beneficial influence on the tumor growth depends on local up regulation of the NOS or ARG pathways at the tumor site. OBJECTIVE: To evaluate the expression profile of ARG and iNOS in various histological subtypes of soft tissue sarcomas (STSs). METHODS: A series of 81 adult STSs were tested for ARG1, ARG2 and iNOS expression by immunohistochemical analysis. RESULTS: ARG1, ARG2 and iNOS expression was found in tumor cells of all cases of STSs except dermatofibrosarcoma protuberans (DFSP) in a cytoplasmic pattern. However, there was no significant correlation found between ARG, iNOS expression and histopathological parameters. Conversely, the majority of DFSP were devoid of ARG and iNOS expression, while only two cases showed focal and weak expression. CONCLUSIONS: Overexpression of L-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs. New knowledge of the regulation of arginine metabolism in tumor tissues is key to designing sound therapeutic means to effectively prevent tumorigenesis. Further studies are needed to clarify the absence of ARG and iNOS staining in DFSP.
机译：背景：L-精氨酸（L-Arg）是人类的有条件必需氨基酸，它是精氨酸酶（ARG）和一氧化氮合酶（iNOS）酶的可诱导形式的底物。 L-Arg代谢是否对肿瘤生长有害或有益，取决于肿瘤部位NOS或ARG途径的局部上调。目的：探讨ARG和iNOS在软组织肉瘤（STSs）各种组织学亚型中的表达情况。方法：采用免疫组织化学方法检测了81例成人STS中ARG1，ARG2和iNOS的表达。结果：除皮肤纤维肉瘤隆突（DFSP）外，所有STS病例的肿瘤细胞均以细胞质表达ARG1，ARG2和iNOS表达。但是，在ARG，iNOS表达与组织病理学参数之间没有发现显着相关性。相反，大多数DFSP缺乏ARG和iNOS表达，而只有2例显示灶性和弱表达。结论：除DFSP外，所有STS病例的肿瘤细胞中L-Arg代谢酶ARG和iNOS的过表达可能在介导表征STS的生物学过程中起作用。肿瘤组织中精氨酸代谢调控的新知识是设计有效预防肿瘤发生的合理治疗手段的关键。需要进一步的研究来阐明DFSP中不存在ARG和iNOS染色。

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