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首页> 外文期刊>Journal of dermatological science >The role of TRPV1 channel in aged human skin
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The role of TRPV1 channel in aged human skin

机译：TRPV1通道在老年人皮肤中的作用

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摘要

Transient receptor potential vanilloid 1 (TRPV1) is a member of the nonselective cationic channel family. Activation of TRPV1 induces an influx of divalent and monovalent cations (i.e., Ca 2+, Na +, and Mg 2+) which are activated by capsaicin, heat, and acid. TRPV1 is known to be expressed in the epidermis, but little is known about the physiological significance and functional role of TRPV1 in skin.Recent studies suggested that heat- and ultraviolet (UV)-induced matrix metalloproteinases-1 (MMP-1) expression may be partly mediated by TRPV1 activation in human keratinocytes. Also, heat and UV increased expression of TRPV1 proteins in human skin in vivo. TRPV1 protein was expressed more in the sun-protected (upper-inner arm) skin of the elderly than in young subjects. In addition, the photoaged (forearm) skin of the elderly showed increased TRPV1 expression compared to sun-protected skin of the same individuals. The increased TRPV1 expression in the old skin implies that TRPV1 may be related to senile skin symptoms, such as senile pruritus and neurogenic inflammation. This review provides a summary of current researches on the role of TRPV1 channel in human skin, especially in aged skin.
机译：瞬态受体电位香草酸1（TRPV1）是非选择性阳离子通道家族的成员。 TRPV1的激活诱导大量的二价和一价阳离子（即Ca 2 +，Na +和Mg 2+）涌入，这些阳离子被辣椒素，热和酸激活。已知TRPV1在表皮中表达，但对TRPV1在皮肤中的生理意义和功能作用知之甚少。最近的研究表明，热和紫外线（UV）诱导的基质金属蛋白酶1（MMP-1）表达可能在人类角质形成细胞中部分被TRPV1激活介导。同样，热量和紫外线在体内增加了人类皮肤TRPV1蛋白的表达。与年轻受试者相比，TRPV1蛋白在老年人的防晒（上臂）皮肤中表达更高。此外，与相同个体的防晒皮肤相比，老年人的光老化（前臂）皮肤显示出增加的TRPV1表达。老皮肤中TRPV1表达的增加意味着TRPV1可能与老年性皮肤症状有关，例如老年性瘙痒和神经源性炎症。这篇综述概述了TRPV1通道在人类皮肤，尤其是老年皮肤中的作用的最新研究。

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