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首页> 外文期刊>Journal of dermatological science >Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis
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Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis

机译：辣椒素治疗新生鼠的慢性复发性瘙痒性皮炎;人类特应性皮炎的潜在大鼠模型

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Background: The pathophysiological mechanisms underlying chronic pruritic skin diseases, e.g. atopic dermatitis (AD), and effective therapies remain elusive due to the paucity of animal models. Recently, we rediscovered that injection of capsaicin into rat pups resulted in vigorous scratching behavior and chronically relapsing AD-like cutaneous lesions well into adulthood. Objectives: To characterize the chronic pruritic dermatitis induced by neonatal capsaicin treatment. Methods: Capsaicin (50. mg/kg) was given to rat pups subcutaneously within 48. h after birth, and then scratching behavior, dermatitis and pathophysiological changes of rat skin were investigated chronologically. Results: Neonatal capsaicin treatment led to not only severe scratching and cutaneous lesions but also a large number of pathophysiological changes in the skin, such as histopathological changes including the deficiency of epidermal filaggrin expression, increases in the number of mast cells, levels of tissue NGF and Th2 cytokine mRNA, impaired skin barrier function and colonization with . S. aureus. In addition, we observed the hyperproduction of serum IgE, which is clinically similar to the pathophysiology seen in the patients with atopic dermatitis. During the follow-up observation, the rats showed the alternative periods of relapsing and remitting skin lesions. Conclusion: Injection of capsaicin into rat pups results in chronically relapsing pruritic dermatitis, similar to human AD. Therefore, we think neonatal capsaicin treatment could be a useful model for studying human AD and for the development of novel therapeutic drugs.
机译：背景：慢性瘙痒性皮肤病（例如，皮肤瘙痒）的病理生理机制。由于缺乏动物模型，特应性皮炎（AD）和有效的疗法仍然难以捉摸。最近，我们重新发现，将辣椒素注射到大鼠幼崽中会导致剧烈的抓挠行为，并将AD样皮肤病变长期复发，直至成年。目的：探讨新生儿辣椒素治疗引起的慢性瘙痒性皮炎的特点。方法：在出生后48小时内皮下注射辣椒素（50. mg / kg）给大鼠幼崽，然后按时间顺序调查其抓挠行为，皮炎和大鼠皮肤的病理生理变化。结果：新生儿辣椒素治疗不仅导致严重的抓挠和皮肤损伤，而且导致皮肤的大量病理生理变化，例如组织病理学变化，包括表皮丝聚蛋白表达不足，肥大细胞数量增加，组织NGF水平和Th2细胞因子mRNA，受损的皮肤屏障功能和定植。金黄色葡萄球菌。此外，我们观察到血清IgE的过度产生，这在临床上与特应性皮炎患者的病理生理学相似。在随访观察中，大鼠显示出皮肤病变复发和缓解的交替时期。结论：向大鼠幼鼠注射辣椒素可导致慢性复发性瘙痒性皮炎，类似于人AD。因此，我们认为新生儿辣椒素治疗可能是研究人类AD和开发新型治疗药物的有用模型。

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