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外文期刊>Journal of dermatological science
>Correlation between the capsaicin test and objective skin measurements in evaluating sensitive skin in Chinese females
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Correlation between the capsaicin test and objective skin measurements in evaluating sensitive skin in Chinese females
Tacrolimus, a topical calcineurin inhibitor, is an immunosup-pressive drug mainly through down-regulation of T cell activation. Topical application of tacrolimus shows therapeutic effect on inflammatory skin diseases such as atopic dermatitis [1 ]. However, there has been a concern about the long term risk of possible skin cancers facilitated by topical tacrolimus, because of its potential suppression of anti-tumor immunity [2]. Recent studies demonstrated that topical pimecrolimus and tacrolimus did not accelerate photocarcinogenesis in hairless mice after UVA or simulated solar radiation [3,4]. In this study, we examined whether or not topical tacrolimus affected the photocarcinogenesis in cancer-prone, K5.Stat3C transgenic mice. Expression of the Stat3C transgene in the keratinocytes allowed them to develop not only psoriasis-like lesion [5], but also squamous cell carcinoma (SCC) through repeated UVB irradiation [6], since Stat3 activation leads to tumor initiation and promotion [7]. Following UVB irradiation, the formation of skin tumors in K5.Stat3C mice is accelerated and both the incidence and multiplicity of skin tumors are significantly greater than wild-type controls [6]. K5.Stat3C mice develop UVB-induced SCC in situ as early as 14 weeks of UVB irradiation, while more than 25 weeks are required in wild-type mice [6-8]. Therefore, the skin cancer-prone K5.Stat3C mice represent a suitable model for early photocarcinogenesis, thereby any impact of immunosuppressive drug could be easily detected.
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