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UV-B induces cytoplasmic survivin expression in mouse epidermis

机译:UV-B诱导小鼠表皮中细胞质survivin表达

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摘要

Excessive exposure to ultra-violet (UV) light, the UV-B component (290-230 nm) in particular, represents the most harmful DNA damage-inducing condition that keratinocytes have to face on a regular basis. UV-B exposure induces survivin expression in keratinocytes in vitro [1] and in vivo [2]. Survivin (BIRC5) is a member of the "inhibitor of apoptosis (IAP)" protein family that can directly or indirectly inhibit caspases, the proteases that mediate apoptosis. Unlike the other members of the family, survivin is also a chromosomal passenger that ensures proper chromosome segregation during cell mitosis.
机译:过度暴露于紫外线(特别是UV-B组分(290-230 nm))是角质形成细胞必须定期面对的最有害的DNA损伤诱导条件。 UV-B暴露在体外[1]和体内[2]诱导角质形成细胞中survivin表达。 Survivin(BIRC5)是“凋亡抑制剂(IAP)”蛋白家族的成员,该蛋白家族可以直接或间接抑制介导凋亡的蛋白酶caspases。与该家族的其他成员不同,survivin还是一种染色体客体,可确保细胞有丝分裂过程中染色体的正确分离。

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