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首页> 外文期刊>Journal of dermatological science >Angiopoietin-like 4, a protein strongly induced during sebocyte differentiation, regulates sebaceous lipogenesis but is dispensable for sebaceous gland function in vivo
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Angiopoietin-like 4, a protein strongly induced during sebocyte differentiation, regulates sebaceous lipogenesis but is dispensable for sebaceous gland function in vivo

机译：脂蛋白样4，一种在皮细胞分化过程中强烈诱导的蛋白，调节皮脂生成，但对于体内皮脂腺功能是必不可少的

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摘要

Sebocytes are extremely specialized epithelial cells that progressively accumulate lipids and release their content by cellular degradation and cell membrane rupture, a process known as holocrine secretion [1]. Their product, including cell debris, is released from the sebaceous gland (SG) into the follicular canal and reaches the skin surface in the form of sebum. While the full range of sebum functions in human skin remains to be clarified, sebum appears to be an important element of the epidermal barrier and the skin immune system [1]. Although the transcription factors and signalling pathways regulating SG development and homeo-stasis are becoming increasingly well-understood, little is known about the transcriptional regulation of sebaceous lipogenesis. Here, we employed the immortalized human SG cell line SZ95 [2] to identify transcripts induced by ciglitazone and linoleic acid (LA) during sebaceous lipogenesis.
机译：皮脂细胞是高度专门化的上皮细胞，它们逐渐积累脂质并通过细胞降解和细胞膜破裂释放其内含物，这一过程称为全分泌激素[1]。它们的产品（包括细胞碎片）从皮脂腺（SG）释放到卵泡管中，并以皮脂的形式到达皮肤表面。尽管皮脂在人皮肤中的全部功能仍有待阐明，但皮脂似乎是表皮屏障和皮肤免疫系统的重要元素[1]。尽管调节SG发育和稳态的转录因子和信号传导途径变得越来越容易理解，但对皮脂生成的转录调控知之甚少。在这里，我们采用了永生化的人SG细胞系SZ95 [2]来确定皮脂脂肪生成过程中由西格列酮和亚油酸（LA）诱导的转录本。

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