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首页> 外文期刊>Journal of Electrocardiology: An International Publication for the Study of the Electrical Activities of the Heart >Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring
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Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring

机译：运动压力测试和动态心电图监测期间评估T波交替蛋白的临床应用

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摘要

Analytical methods to measure T-wave alternans (TWA), a beat-to-beat fluctuation in the morphology of the ST-segment and T wave in the electrocardiogram (ECG), have been developed to address the unmet challenge of identifying individuals at increased risk for sudden cardiac death. Conventional noninvasive markers including left ventricular ejection fraction have significant limitations as many individuals who die suddenly have relatively preserved ventricular mechanical function. TWA is an attractive marker as it is closely linked to ECG heterogeneity and abnormalities in calcium handling, key factors in arrhythmogenesis. The objectives of this review are to summarize the clinical evidence supporting use of TWA in risk stratification and to discuss its current and potential applications in guiding device and medical therapy.
机译：已经开发出了用于测量T波交替蛋白（TWA），心电图（ECG）中ST段和T波形态的逐搏波动的分析方法，以解决识别个体在高心脏猝死的风险。常规的非侵入性标志物包括左心室射血分数有明显的局限性，因为许多突然死亡的个体具有相对保留的心室机械功能。 TWA是有吸引力的标记，因为它与ECG异质性和钙处理异常（心律失常的关键因素）密切相关。这篇综述的目的是总结支持在危险分层中使用TWA的临床证据，并讨论其在引导装置和药物治疗中的当前和潜在应用。

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