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首页> 外文期刊>Biomolecules & therapeutics >Evaluation of Anti-Colitic Effect of Chung-Jang-Hwan (C-mix) in Mice
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Evaluation of Anti-Colitic Effect of Chung-Jang-Hwan (C-mix) in Mice

机译：钟长焕（C-mix）对小鼠抗结肠炎作用的评价

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The inhibitory effect of Chung-Jang-Hwan (C-mix) consisted of Geranium nepalense subsp. thunbergii, Saururus chinensis, and Rubus coreanus were investigated in dextran sulfate sodium (DSS)-induced colitic mice by microarray analysis. Treatment with C-mix improved colitic symptoms, including colon shortening and myeloperoxidase activity. Treatment with DSS alone upregulated the expression levels of inflammation-related genes, including IL-1f}, IL-6, CCL2, CCL4, CCL5, CCL7, CCL8, CCL24, CXCL1, CXCL2, CXCL5, CXCL9 and CXCL10, and other colitis-related genes such as COX-2, PAP, MMP family, S100a8, S100a9 and DEFA1 in mice. However, treatment with C-mix inhibited the expression levels of inflammation-associated genes induced by DSS. The increased expression levels of COX-2 and IL-1/3, representative inflammatory genes, were confirmed by a quantitative realtime polymerase chain reaction analysis. These results indicate that C-mix may ameliorate colitis by the inhibitory regulation of inflammation-associated genes.
机译：钟张焕（C-mix）的抑制作用由尼泊尔天竺葵亚种组成。通过微阵列分析在硫酸葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠中研究了雷氏杜鹃，金毛龙和大红悬钩子。用C-mix进行治疗可改善结肠症状，包括结肠缩短和髓过氧化物酶活性。单独用DSS进行治疗可上调炎症相关基因的表达水平，包括IL-1f}，IL-6，CCL2，CCL4，CCL5，CCL7，CCL8，CCL24，CXCL1，CXCL2，CXCL5，CXCL9和CXCL10，以及其他结肠炎相关基因，例如小鼠中的COX-2，PAP，MMP家族，S100a8，S100a9和DEFA1。但是，用C-mix处理可抑制DSS诱导的炎症相关基因的表达水平。实时定量聚合酶链反应分析证实了代表性炎症基因COX-2和IL-1 / 3的表达水平增加。这些结果表明，C-mix可通过抑制炎症相关基因来改善结肠炎。

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