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首页> 外文期刊>Journal of cosmetic and laser therapy >Response of spider leg veins to pulsed diode laser (810 nm): a clinical, histological and remission spectroscopy study.
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Response of spider leg veins to pulsed diode laser (810 nm): a clinical, histological and remission spectroscopy study.

机译：蜘蛛腿静脉对脉冲二极管激光（810 nm）的响应：临床，组织学和缓解光谱学研究。

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BACKGROUND: Spider leg veins are common. Their treatment with laser or intensed light therapy shows generally variable success rates and often adverse side effects such as hyper- or hypopigmentation. This study was performed to investigate whether pulsed diode laser (810 nm) treatment is effective and safe. METHODS: Thirty-five female patients with spider leg veins were included in this prospective trial. They were treated twice with a pulsed diode laser (810 nm; spot size 12 mm, frequency 2-4 Hz, pulse width 60 msec, fluence 80-100 Jcm(-2)). Laser therapy was performed on day 0 and day 14. Clinical assessments were carried out before and immediately after the first laser therapy, after 2 weeks, 8 weeks, and one year. Skin biopsies were taken before and immediately after the first laser treatment, and after 10 weeks. Contact-free remittance spectroscopy was performed before laser treatment, immediately after the first treatment, after 2 weeks and 8 weeks. RESULTS: After the first treatment 15 patients showed a complete disappearance (CR) of spider leg veins; in the remaining 20 patients a remarkable improvement (RI) was noted (n=35). After six months of follow-up CR was seen in 6 patients, RI in 6, a stable situation in 9, and scar formation in 1 patient (n=21). The effect was almost completely stable during one year of follow-up. The examination of histological specimens before and after laser treatment showed no cellular inflammatory reaction. The mean vascular area was significantly reduced after the first (p<0.05) and after the second (p<0.05) laser treatment. Spectral analysis showed a marked decrease of peaks for oxygenized haemoglobin immediately after laser treatment and during the follow-up. Safety profile was excellent without purpuric reaction or pigmentary changes. Mild scarring was observed in two patients at the end of follow-up. CONCLUSIONS: Pulsed diode laser therapy (810 nm) is an effective and safe treatment option for spider leg veins. The effects can be seen immediately. Objective monitoring by non-invasive remission spectroscopy and histology of biopsy specimens demonstrates selectivity of the laser action.
机译：背景：蜘蛛腿静脉很常见。他们使用激光或强光疗法的治疗通常显示出不同的成功率，并且经常出现不良的副作用，例如色素沉着或色素沉着不足。进行这项研究以研究脉冲二极管激光（810 nm）治疗是否有效和安全。方法：该前瞻性研究纳入了35例女性的蜘蛛腿静脉女性患者。他们用脉冲二极管激光器（810 nm;光斑尺寸12 mm，频率2-4 Hz，脉冲宽度60毫秒，通量80-100 Jcm（-2））治疗两次。在第0天和第14天进行激光治疗。在第一次激光治疗之前和之后，2周，8周和一年后进行临床评估。在第一次激光治疗之前和之后以及之后10周进行皮肤活检。在激光治疗之前，第一次治疗之后，2周和8周之后进行非接触式汇兑光谱。结果：首次治疗后15例患者显示蜘蛛腿静脉完全消失（CR）。在其余20位患者中，有显着改善（RI）（n = 35）。经过六个月的随访，发现6例CR，6例RI，9例稳定，1例形成疤痕（n = 21）。在随访的一年中，效果几乎完全稳定。激光治疗前后的组织学标本检查未见细胞炎性反应。第一次（p <0.05）和第二次（p <0.05）激光治疗后，平均血管面积明显减少。光谱分析显示，在激光治疗后和随访期间，含氧血红蛋白的峰明显减少。安全性极好，无紫癜反应或色素变化。随访结束时在两名患者中观察到轻度瘢痕形成。结论：脉冲二极管激光疗法（810 nm）是治疗蜘蛛腿静脉的有效且安全的选择。效果可以立即看到。通过非侵入性缓解光谱学和活检标本的组织学进行的客观监测证明了激光作用的选择性。

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