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首页> 外文期刊>Journal of cosmetic dermatology >Aging of hair
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Aging of hair

机译：头发老化

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The appearance of hair plays an important role in people's overall physical appearance and self-perception. With today's increasing life expectation, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this and also more capable to deliver active products that are directed toward meeting this consumer demand. The discovery of pharmacological targets and the development of safe and effective drugs also indicate strategies of the drug industry for maintenance of healthy and beautiful hair. Hair aging comprises weathering of the hair shaft and aging of the hair follicle. The latter manifests as decrease of melanocyte function or graying, and decrease in hair production in androgenetic and senescent alopecia. The scalp is also subject to intrinsic or physiologic aging and extrinsic aging caused by external factors. Intrinsic factors are related to individual genetic and epigenetic mechanisms with interindividual variation. Prototypes are familial premature graying and androgenetic alopecia. Extrinsic factors include ultraviolet radiation and smoking. Experimental evidence supports the hypothesis that oxidative stress plays a role in skin and hair aging. Topical anti-aging compounds for hair include humefactants, hair conditioners, photoprotectors, and anti-oxidants. Current available treatment modalities with proven efficacy for treatment of androgenetic alopecia are topical minoxidil, oral finasteride, and autologous hair transplantation. In the absence of another way to reverse hair graying, hair colorants are the mainstays of recovering lost hair color. Topical liposome targeting for melanins, genes, and proteins selectively to hair follicles are under current investigation.
机译：头发的外观在人们的整体外观和自我认知中起着重要作用。随着当今人们对寿命的期望越来越高，对看起来年轻的渴望起着比以往更大的作用。护发行业已经意识到这一点，并且也更有能力交付旨在满足这种消费者需求的活性产品。药理学目标的发现以及安全有效药物的开发也表明了制药业保持健康美丽头发的策略。头发老化包括发干的风化和毛囊的老化。后者表现为黑素细胞功能降低或变灰，以及雄激素性和衰老性脱发的毛发生长减少。头皮还容易受到外部因素引起的内在或生理老化和外在老化的影响。内在因素与个体间变异的个体遗传和表观遗传机制有关。原型是家族性过早变灰和雄激素性脱发。外在因素包括紫外线辐射和吸烟。实验证据支持氧化应激在皮肤和头发老化中起作用的假说。用于头发的局部抗衰老化合物包括保湿剂，头发调理剂，光保护剂和抗氧化剂。具有治疗雄激素性脱发的功效的当前可用治疗方式为局部用米诺地尔，口服非那雄胺和自体毛发移植。在没有另一种逆转头发变白的方法的情况下，染发剂是恢复失去的发色的主要手段。针对黑色素，基因和蛋白质选择性地靶向毛囊的局部脂质体目前正在研究中。

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