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首页> 外文期刊>Journal of cosmetic dermatology >Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone
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Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone

机译：0.5％和1.0％艾地苯醌对光损伤皮肤的临床疗效评估

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Idebenone is an antioxidant lower molecular weight analogue of coenzyme Q1Q. Previously, idebenone was shown to be a very effective antioxidant in its ability to protect against cell damage from oxidative stress in a variety of biochemical, cell biological, and in vivo methods, including its ability to suppress sunburn cell (SBC) formation in living skin. However, no clinical studies have been previously conducted to establish the efficacy of idebenone in a topical skincare formulation for the treatment of photodamaged skin. In this nonvehicle control study, 0.5% and 1.0% idebenone commercial formulations were evaluated in a clinical trial for topical safety and efficacy in photodamaged skin. Forty-one female subjects, aged 30-65, with moderate photodamaged skin were randomized to use a blind labelled (either 0.5% or 1.0% idebenone in otherwise identical lotion bases) skincare preparation twice daily for six weeks. Blinded expert grader assessments for skin roughness/dryness, fine lines/wrinkles, and global improvement in photodamage were performed at baseline, three weeks and six weeks. Electrical conductance readings for skin surface hydration and 3 5 mm digital photography were made at baseline after six weeks. Punch biopsies were taken from randomly selected subjects, baseline and after six weeks, and stained for certain antibodies (interleukin IL-6, interleukin IL-lb, matrixmetallopro-teinase MMP-1, collagen I) using immunofluorescence microscopy. After six weeks' use of the 1.0% idebenone formula, a 26% reduction in skin roughness/dryness was observed, a 3 7% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 3 3% improvement in overall global assessment of photodamaged skin. For the 0.5% idebenone formulation, a 23% reduction in skin roughness/dryness was observed, a 3 7% increase in skin hydration, a 2 7% reduction in fine lines/wrinkles, and a 30% improvement in overall global assessment of photodamaged skin. The immunofluorescence staining revealed a decrease in IL-lb, IL-6, and MMP-1 and an increase in collagen I for both concentrations.
机译：艾地苯醌是辅酶Q1Q的抗氧化剂低分子量类似物。以前，艾地苯醌已被证明是一种非常有效的抗氧化剂，可以通过多种生化，细胞生物学和体内方法保护细胞免受氧化应激的损害，包括抑制活体皮肤晒伤细胞（SBC）形成的能力。 。然而，以前尚未进行临床研究来确定艾地苯醌在局部皮肤护理制剂中用于治疗光损伤皮肤的功效。在这项非车辆对照研究中，在临床试验中评估了0.5％和1.0％艾地苯醌市售制剂在光损伤皮肤中的局部安全性和功效。随机将41位年龄在30-65岁，皮肤受到中度光损伤的女性受试者随机分为两组，每天使用两次盲法标记的皮肤护理制剂（在相同的乳液中使用0.5％或1.0％的艾地苯醌），每天两次。在基线，三周和六周时，对皮肤粗糙/干燥，细纹/皱纹和光损伤的整体改善进行了盲目专家评分。六周后，在基线时获取皮肤表面水化的电导读数和3个5毫米数码照片。从随机选择的受试者，基线和六周后进行打孔活检，并使用免疫荧光显微镜对某些抗体（白介素IL-6，白介素IL-1b，基质金属蛋白酶MMP-1，胶原蛋白I）染色。使用1.0％艾地苯醌配方六周后，皮肤粗糙度/干燥度降低了26％，皮肤水合作用增加了37％，细纹/皱纹减少了29％，而3％改善了3％。对受损皮肤进行整体评估。对于0.5％的艾地苯醌制剂，观察到的皮肤粗糙度/干燥度降低了23％，皮肤水合作用的增加了37％，细纹/皱纹的减少了27％，整体的光损伤评估提高了30％皮肤。免疫荧光染色显示两种浓度的IL-1b，IL-6和MMP-1减少，而胶原I增加。

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