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Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation

机译:异基因造血干细胞移植后的膜增生性肾小球肾炎

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摘要

Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated membranoproliferative glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I membranoproliferative glomerulonephritis. Salivary gland biopsy demonstrated mild lymphocytic infiltration, indicating chronic GVHD. Improvement of the proteinuria and recovery of renal function were achieved within 11 months of treatment with oral prednisolone and azathioprine.
机译:同种异体造血干细胞移植后的肾病综合征已被越来越多地描述为慢性移植物抗宿主病(GVHD)的表现。然而,与GVHD相关的膜增生性肾小球肾炎极为罕见。一名44岁的男子因急性淋巴细胞白血病在HSCT后24个月发展为肾病综合征。肾活检显示I型膜增生性肾小球肾炎。唾液腺活检显示轻度淋巴细胞浸润,提示慢性GVHD。口服泼尼松龙和硫唑嘌呤治疗后11个月内,蛋白尿改善和肾功能恢复。

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