...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of endovascular therapy: an official journal of the International Society of Endovascular Specialists >Histological changes in canine aorta 1 year after stent-graft implantation: implications for the long-term stability of device anchoring zones.
【24h】

Histological changes in canine aorta 1 year after stent-graft implantation: implications for the long-term stability of device anchoring zones.

机译：支架植入后1年犬主动脉的组织学变化：对装置锚固区的长期稳定性的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To examine aortic histology 1 year after stent-graft implantation in a canine model as a means of assessing the durability of endograft fixation. METHODS: Fourteen mongrel dogs each received 1 stent-graft and 1 bare stent placed endoluminally in the abdominal aorta. Eight animals were followed for 1 year, 3 for 4 to 8 weeks, and the remaining 3 for 24 to 48 hours. Aortic specimens were stained with hematoxylin-eosin, elastica-van Gieson, and Masson's trichrome and examined with light and electron microscopy and immunohistochemistry to identify smooth muscle cells (SMC), endothelialization, aortic wall ultrastructure, and changes at the device anchoring sites. RESULTS: No dilatation or dissection was noted at any of the device anchoring sites. The aortic media at 1 year was remarkably decreased in thickness: 891 +/- 196 microm in the control tissue versus 388 +/- 70 microm for the proximal stent-grafted aorta and 457 +/- 148 microm for the bare-stented aortic segment. Other important histological features were reduced elastic lamellae in the stent-grafted aorta versus control (p<0.0001), increased SMC density in the stent-grafted aortic region (p<0.0001 versus control), and absence of inflammatory infiltrate. Complete neointimal covering and endothelialization of the luminal endograft surface were found. SMCs generally showed no ultrastructural features of necrosis. CONCLUSIONS: Aortic stent-grafts induce distinctive histological changes in the aortic wall at 1 year, even when implanted in a healthy aorta. Although there is considerable medial elastin loss, an increased medial SMC density, an exuberant neointima, and a general absence of perigraft inflammation suggest an ongoing process of structural restoration at the device anchoring sites.
机译：目的：在犬模型中植入支架移植物一年后检查主动脉组织学，以评估移植物内固定的持久性。方法：14只杂种狗每只接受1个支架移植物和1个裸露支架腔内放置在腹主动脉中。追踪八只动物，为期一年，三只为期4至8周，其余三只为时24至48小时。主动脉标本用苏木精-曙红，elastica-van Gieson和Masson三色染色，并用光电子显微镜和免疫组织化学检查，以鉴定平滑肌细胞（SMC），内皮化，主动脉壁超微结构以及装置锚定位点的变化。结果：在任何装置锚固部位均未发现扩张或解剖。 1年时主动脉介质的厚度明显减少：对照组织中的891 +/- 196微米，而近端支架移植的主动脉为388 +/- 70微米，裸支架主动脉段为457 +/- 148微米。其他重要的组织学特征是支架移植的主动脉相对于对照的弹性片层减少（p <0.0001），支架移植的主动脉区域中的SMC密度增加（相对于对照，p <0.0001）以及不存在炎性浸润。发现完整的新内膜覆盖和腔内移植物表面的内皮化。 SMC通常没有坏死的超微结构特征。结论：即使植入健康的主动脉，主动脉支架移植物也可在1年时在主动脉壁上引起明显的组织学变化。尽管内侧弹性蛋白大量损失，但内侧SMC密度增加，新生内膜旺盛以及移植物周围炎症的普遍缺失提示装置锚固位点正在进行结构恢复的过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号