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首页> 外文期刊>Journal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology >Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand in post-menopausal women.
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Circulating profiles of osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand in post-menopausal women.

机译：绝经后妇女骨保护素和核因子κB配体的可溶性受体激活剂的循环概况。

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OBJECTIVE: The aim of this study was to elucidate the detail profiles of circulating osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappaB ligand (sRANKL) in post-menopausal women. METHODS: Eighty Japanese post-menopausal women were enrolled in this cross-sectional study. Circulating OPG and free fraction of sRANKL (free sRANKL), PTH, calcium and phosphorus, age, years since menopause, body mass index, bone mineral density of the vertebral bodies (LBMD) and bone turnover markers were determined in each subject. RESULTS: In rank order correlation analysis, serum OPG concentrations had a significant positive correlation with age (r=0.291, p=0.024) and a marginal significant negative correlation with LBMD (r=-0.247, p=0.062). However they did not have correlations with LBMD or other parameters after adjustment for age. Serum free sRANKL concentrations had a significant positive correlation with age (r=0.332, p=0.010) and a significant negative correlation with LBMD (r=-0.608, p<0.001). This correlation with LBMD persisted after adjustment for age. In a multiple regression analysis with a stepwise model, the main determinants of LBMD were age and serum free sRANKL (p=0.015 and p=0.006, respectively). CONCLUSIONS: We found the increase in circulating OPG and sRANKL with age and a robust negative correlation between circulating free sRANKL and LBMD after adjustment for age. The increase in circulating free sRANKL may reflect directly or indirectly the conditions coexistent with bone loss in post-menopausal women.
机译：目的：本研究的目的是阐明绝经后妇女循环骨保护素（OPG）和核因子κB配体（sRANKL）的可溶性受体激活剂的详细情况。方法：80名日本绝经后妇女参加了这项横断面研究。确定每个受试者的循环OPG和sRANKL的游离分数（游离sRANKL），PTH，钙和磷，年龄，绝经后的年限，体重指数，椎体的骨矿物质密度（LBMD）和骨转换标记。结果：在等级相关分析中，血清OPG浓度与年龄呈显着正相关（r = 0.291，p = 0.024），与LBMD呈显着负相关（r = -0.247，p = 0.062）。但是，在调整年龄后，它们与LBMD或其他参数没有相关性。无血清sRANKL浓度与年龄呈显着正相关（r = 0.332，p = 0.010），与LBMD呈显着负相关（r = -0.608，p <0.001）。调整年龄后，与LBMD的相关性仍然存在。在逐步模型的多元回归分析中，LBMD的主要决定因素是年龄和无血清sRANKL（分别为p = 0.015和p = 0.006）。结论：我们发现随着年龄的增长，循环OPG和sRANKL随年龄的增加而增加，并且循环自由sRANKL和LBMD之间存在显着的负相关。循环中游离sRANKL的增加可能直接或间接反映了绝经后妇女骨质流失并存的状况。

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