...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of endotoxin research >A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions.
【24h】

A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions.

机译：一种检测核苷酸受体P2X7遗传多态性影响许多先天免疫功能的新方法。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The importance of accessory signaling pathways amplifying endotoxin responses has recently been highlighted by genetic studies describing LPS-hyporesponsive individuals despite carrying the common allele for TLR4. The nucleotide receptor P2X7 modulates the production of numerous LPS-stimulated inflammatory mediators. We have recently described the largest phenotypic screen known for genetic polymorphisms associated with the nucleotide receptor P2X7, a global regulator of leukocyte function. This required the development of a novel monocyte pore assay with numerous advantages over previous methods and with the potential to facilitate rapid (< 3 h), multiplex analysis of clinical samples. This paper addresses aspects pertinent to the development of the monocyte pore assay, briefly summarizes our results suggesting that P2X7 alleles modulate LPS-stimulated cytokine production, and discusses a model wherein P2X7 may serve as an amplification loop of innate immunity.
机译：遗传学研究描述了LPS低反应性个体，尽管携带了TLR4的常见等位基因，但近来辅助基因信号通路放大内毒素反应的重要性已被基因研究突显。核苷酸受体P2X7调节多种LPS刺激的炎症介质的产生。我们最近描述了最大的表型筛选，该表型因与核苷酸受体P2X7（白细胞功能的全球调节剂）相关的遗传多态性而闻名。这需要开发一种新颖的单核细胞孔测定法，该方法具有比以前的方法众多的优势，并且有可能促进临床样品的快速（<3小时）多重分析。本文探讨了与单核细胞孔测定法发展有关的方面，简要总结了我们的结果，表明P2X7等位基因调节LPS刺激的细胞因子产生，并讨论了其中P2X7可以充当先天性免疫放大环的模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号