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首页> 外文期刊>Journal of endotoxin research >Detection of endotoxin in sera from children hospitalized for treatment of diarrhea in Bangladesh.
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Detection of endotoxin in sera from children hospitalized for treatment of diarrhea in Bangladesh.

机译：从孟加拉国住院治疗腹泻的儿童中检测血清中的内毒素。

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The level of circulating endotoxin was determined in the sera from children hospitalized for treatment of diarrhea at the International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. A significant level of endotoxin was detected in the sera from 23 (54%) of 42 children. On the other hand, in 32 normal controls, endotoxin was below the limits of detection of the assay. Antibiotic and fluid therapy markedly reduced the level of serum endotoxin and improved the general condition of most patients. Non-survivors (n = 5) had higher levels of circulating endotoxin before treatment than survivors (n = 37), suggesting a significant correlation between the serum endotoxin level before treatment and mortality. Malnutrition did not affect the serum endotoxin level in the patients with diarrhea. It was suggested that infection of Gram-negative bacteria might be involved in a significant number of patients with diarrhea in Bangladesh and that endotoxin might play a pathogenic role in those patients.
机译：在孟加拉国达卡国际腹泻病研究中心，从住院治疗腹泻的儿童的血清中测定了循环内毒素的水平。在42名儿童中，有23名（54％）的血清中检测到明显的内毒素水平。另一方面，在32个正常对照中，内毒素低于检测限。抗生素和液体疗法显着降低了血清内毒素水平，并改善了大多数患者的总体状况。非存活者（n = 5）治疗前的循环内毒素水平高于存活者（n = 37），表明治疗前血清内毒素水平与死亡率之间存在显着相关性。营养不良不影响腹泻患者的血清内毒素水平。有人认为，孟加拉国大量腹泻患者可能感染了革兰氏阴性细菌，内毒素可能在这些患者中发挥致病作用。

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