Patterns of Innovation in Alzheimer's Disease Drug Development: A Strategic Assessment Based on Technological Maturity

Beierlein Jennifer M.; McNamee Laura M.; Walsh Michael J.; Ledley Fred D.

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Patterns of Innovation in Alzheimer's Disease Drug Development: A Strategic Assessment Based on Technological Maturity

机译：阿尔茨海默氏病药物开发的创新模式：基于技术成熟度的战略评估

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Purpose: This article examines the current status of translational science for Alzheimer's disease (AD) drug discovery by using an analytical model of technology maturation. Previous studies using this model have demonstrated that nascent scientific insights and inventions generate few successful leads or new products until achieving a requisite level of maturity. This article assessed whether recent failures and successes in AD research follow patterns of innovation observed in other sectors.

机译：目的：本文通过使用技术成熟度分析模型，研究了阿尔茨海默氏病（AD）药物发现的转化科学的现状。以前使用该模型的研究表明，新生的科学见解和发明在达到必要的成熟度之前，几乎不会产生成功的线索或新产品。本文评估了AD研究中最近的失败和成功是否遵循了其他行业中观察到的创新模式。

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《Clinical therapeutics》 |2015年第8期|共9页
作者
Beierlein Jennifer M.; McNamee Laura M.; Walsh Michael J.; Ledley Fred D.;
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正文语种 eng
中图分类治疗学;
关键词
Alzheimer's disease; Amyloid; Drug development; Innovation; Quantitative modeling;

机译：阿尔茨海默氏病;淀粉样蛋白;药物开发;创新;定量建模;

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1. Patterns of Innovation in Alzheimer's Disease Drug Development: A Strategic Assessment Based on Technological Maturity [J] . Beierlein Jennifer M., McNamee Laura M., Walsh Michael J., Clinical therapeutics . 2015,第8期

机译：阿尔茨海默氏病药物开发的创新模式：基于技术成熟度的战略评估
2. Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." Innovations in care that advance Alzheimer's disease drug development. [J] . Foster NL, Andersen TC, Zamrini EY Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2009,第2期

机译：关于“预防痴呆症的路线图II。莱昂·塔尔研讨会2008”的评论。促进阿尔茨海默氏病药物开发的护理创新。
3. Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer’s Disease Spectrum: Development of the Classifier and Longitudinal Evaluation [J] . Jin San Lee, Changsoo Kim, Jeong-Hyeon Shin, Scientific reports. . 2018,第1期

机译：基于机器学习的Alzheimer疾病思路皮质萎缩模式的单独评估：分类器和纵向评估的发展
4. The method of risk assessment for technological innovation and the pattern of risk investigation based on patent analysis [C] . Song LIU, Yu-qin LIU, Xue-feng WANG 2008 International Conference on Risk and Relianility Management(2008风险与可靠性管理国际会议)论文集 . 2008

机译：基于专利分析的技术创新风险评估方法及风险调查模式
5. Development of a Human Stem Cell-Based Blood-Brain Barrier Model and Its Use in the Study of Drug Transport in Alzheimer's Disease [D] . Mantle, Jennifer L. 2017

机译：基于人干细胞的血脑屏障模型的发展及其在阿尔茨海默病中药转运研究中的应用
6. Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer’s Disease Spectrum: Development of the Classifier and Longitudinal Evaluation [O] . Jin San Lee, Changsoo Kim, Jeong-Hyeon Shin, -1

机译：基于机器学习的阿尔茨海默氏病谱中皮质萎缩模式的个体评估：分类器的开发和纵向评估
7. Patterns of Innovation in Alzheimer’s Disease Drug Development: A Strategic Assessment Based on Technological Maturity [O] . Beierlein Jennifer M., McNamee Laura M., Walsh Michael J., 2015

机译：阿尔茨海默氏病药物开发的创新模式：基于技术成熟度的战略评估

Patterns of Innovation in Alzheimer's Disease Drug Development: A Strategic Assessment Based on Technological Maturity

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