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首页> 外文期刊>Journal of environmental monitoring: JEM >Aluminium uptake and excretion in potroom workers of a new primary aluminium smelter during the construction stage
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Aluminium uptake and excretion in potroom workers of a new primary aluminium smelter during the construction stage

机译：在建造阶段，新的初级铝冶炼厂的车间工人的铝吸收和排泄

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The aim of this study was to define bio-accumulation and excretion patterns of aluminium in newly employed potroom workers as well as changes in ambient aluminium levels in the potrooms of a modern aluminium smelter during the plant construction stage and one year into full production. A study was carried out on 115 newly employed volunteer potroom workers at various intervals, over a total period of 36 months. Before commencement of employment a structured questionnaire was completed by all study participants and the first collection of blood and urine specimens took place. As none of the subjects had ever worked in the aluminium industry before, they also served as their own controls. Atomic absorption spectroscopy was used to measure the aluminium content in the biological fluids and the content of the metal in the ambient air of the potrooms. Significantly, the study found an early and marked biological response to inhalation of very low levels of airborne aluminium. After only 12 months, the mean concentration of aluminium in serum had almost doubled; thereafter it levelled off. A mixed model analysis did not find any differences in the concentrations of aluminium in the serum of the subjects since the variation between subjects at any given time was much smaller than the variation within subjects. This may be an indication of the pronounced effect of aluminium inhalation on the kinetics of this metal in the human body. Furthermore, urinary excretion of aluminium by the potroom workers showed a linear increase reaching a concentration of only 49 μg 1~(-1) at the 36 month stage, suggesting a slow rate of elimination.
机译：这项研究的目的是确定新雇用的车间工人中铝的生物富集和排泄方式，以及在工厂建设阶段和满负荷生产的一年中，现代铝冶炼厂的车间铝中环境铝含量的变化。在总共36个月的期间内，以不同的间隔对115名新雇用的自愿性车间工人进行了研究。在开始雇用之前，所有研究参与者均完成了一份结构化问卷，并且首次收集了血液和尿液样本。由于以前没有人曾在铝行业工作过，因此他们也充当了自己的控制角色。原子吸收光谱法用于测量生物液体中铝的含量以及车间环境空气中金属的含量。重要的是，该研究发现了对吸入极少量空气中铝的早期且显着的生物学反应。仅12个月后，血清中铝的平均浓度几乎增加了一倍;之后它趋于平稳。混合模型分析未发现受试者血清中铝浓度的任何差异，因为受试者在任何给定时间的变化远小于受试者内部的变化。这可能表明铝吸入对这种金属在人体中的动力学有明显的影响。此外，车间工人尿铝的排泄呈线性增加，在36个月阶段达到49μg1〜（-1）的浓度，表明清除速度缓慢。

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