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首页> 外文期刊>Dementia and geriatric cognitive disorders >Plasma homocysteine levels and different forms of vascular disease in patients with dementia and other psychogeriatric diseases.
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Plasma homocysteine levels and different forms of vascular disease in patients with dementia and other psychogeriatric diseases.

机译：痴呆和其他老年精神病患者的血浆同型半胱氨酸水平和不同形式的血管疾病。

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摘要

BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in patients with psychogeriatric disease. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. METHOD: We investigated plasma tHcy levels in several different subgroups of vascular disease and also the relation between plasma tHcy and renal function in patients with psychogeriatric disease. RESULTS: All different groups of patients with vascular disease exhibited an elevated level of plasma tHcy compared to patients without vascular disease even after exclusion of patients with folate/cobalamin deficiency. Patients with elevated serum creatinine with or without vascular disease exhibited significantly increased plasma tHcy compared to the respective groups of patients without elevated serum creatinine. Patients with vascular dementia and Alzheimer's disease with concomitant vascular disease exhibited significantly increased plasma tHcy levels compared to patients without vascular disease. CONCLUSION: The presence of vascular disease increases the level of plasma tHcy and renal impairment further increases the elevated plasma tHcy level. Furthermore, the findings suggest similar influence on plasma tHcy turnover irrespective of whether the vascular disease is of cerebral or extracerebral origin or only manifests itself as arrhythmia or hypertension.
机译：背景：患有老年精神病的患者血浆总同型半胱氨酸（tHcy）浓度升高。血浆tHcy浓度有许多不同的决定因素，包括是否存在血管疾病。方法：我们调查了几个不同血管疾病亚组的血浆tHcy水平，以及精神病患者血浆tHcy与肾功能的关系。结果：即使排除叶酸/钴胺素缺乏症患者，所有不同类别的血管疾病患者的血浆tHcy水平均高于无血管疾病患者。与没有血清肌酐升高的各组患者相比，血清肌酐升高或无血管疾病的患者血浆tHcy明显升高。与没有血管疾病的患者相比，患有血管性痴呆和阿尔茨海默氏病并发血管疾病的患者血浆tHcy水平显着提高。结论：血管疾病的存在增加血浆tHcy水平，而肾功能不全进一步增加血浆tHcy水平。此外，研究结果表明，无论血管疾病是脑源性或脑外源性，还是仅表现为心律不齐或高血压，对血浆tHcy周转率的影响都相似。

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