Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity.

Jarvest RL; Berge JM; Brown P; Houge Frydrych CS; OHanlon PJ; McNair DJ; Pope AJ; Rittenhouse S

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity.

【24h】

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity.

机译：甲硫氨酰tRNA合成酶抑制剂的构象限制导致类似物具有强力抑制作用和出色的革兰氏阳性抗菌活性。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Conformationally restricted analogues of the central linker unit of bacterial methionyl tRNA synthetase (MRS) inhibitors have been prepared. The (1S,2R)-cyclopentylmethyl moiety was identified as the preferred cyclic linker, with significant diastereo- and enantioselectivity of activity. Combination of this linker with an optimal substituted aryl right-hand side has resulted in a compound with exceptionally good antibacterial activity against staphylococci and enterococci, including antibiotic resistant strains.

机译：已经制备了细菌甲硫氨酰tRNA合成酶（MRS）抑制剂的中央接头单元的构象受限的类似物。（1S，2R）-环戊基甲基部分被确定为优选的环状连接基，具有明显的非对映选择性和对映选择性。该接头与最佳取代的芳基右手侧的组合产生了一种对葡萄球菌和肠球菌具有极佳抗菌活性的化合物，包括抗药性菌株。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2003年第7期|共4页
作者
Jarvest RL; Berge JM; Brown P; Houge Frydrych CS; OHanlon PJ; McNair DJ; Pope AJ; Rittenhouse S;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
inhibitors; RNA; Transfer; gram; Positive; Psychological inhibition; RNA; 转移;

机译：inhibitors;RNA;Transfer;gram;Positive;Psychological inhibition;RNA;转移;

相似文献

外文文献
中文文献
专利

1. Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity. [J] . Jarvest RL, Berge JM, Brown P, Bioorganic and Medicinal Chemistry Letters . 2003,第7期

机译：甲硫氨酰tRNA合成酶抑制剂的构象限制导致类似物具有强力抑制作用和出色的革兰氏阳性抗菌活性。
2. Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity. [J] . Jarvest RL, Berge JM, Brown MJ, Bioorganic and Medicinal Chemistry Letters . 2003,第4期

机译：优化芳基取代可产生具有出色革兰氏阳性抗菌活性的有效甲硫氨酰tRNA合成酶抑制剂。
3. Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens [J] . Jarvest RL., Berge JM., Berry V., Journal of Medicinal Chemistry . 2002,第10期

机译：纳摩尔金黄色葡萄球菌甲硫氨酰tRNA合成酶抑制剂对革兰氏阳性病原体具有有效的抗菌活性
4. Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes [O] . Daniel R. Gentry, Karen A. Ingraham, Michael J. Stanhope, 2003

机译：对细菌甲硫氨酰-tRNA合成酶抑制剂的可变敏感性揭示了肺炎链球菌亚群与两个不同的甲硫氨酰-tRNA合成酶基因。
5. Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes [O] . Gentry, Daniel R., Ingraham, Karen A., Stanhope, Michael J., 2003

机译：对细菌甲硫氨酰-tRNA合成酶抑制剂的可变敏感性揭示了肺炎链球菌亚群与两个不同的甲硫氨酰-tRNA合成酶基因。

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity.

摘要

著录项

相似文献

相关主题

期刊订阅