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首页> 外文期刊>Journal of experimental & clinical cancer research : >Added value of blue dye in sentinel node biopsy for breast cancer.
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Added value of blue dye in sentinel node biopsy for breast cancer.

机译：蓝色染料在乳腺癌前哨淋巴结活检中的附加价值。

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Sentinel node biopsy in breast cancer is a new rapidly advancing minimal invasive procedure which enables nodal staging of clinically node negative breast cancer patients without performing complete axillary dissection. There are still controversies over the added value of Blue Dye when lymphoscintigraphy and gamma probe are used. In our series, 91 consecutive patients with invasive breast carcinoma were operated by a single surgeon, using lymphoscintigraphy, gamma probe and Blue Dye. The sentinel nodes (SLN) were histologically examined by HE and immunohistochemistry. Lymphoscintigraphy was succesful in 81 patients (89%). After the injection of Blue Dye, SLN could be identified in all 91 patients. Metastases in the SLN were present in 35 patients. We retrieved 128 SLN, of these 93 were hot and blue, 19 only hot and 16 only blue. The distribution of metastatic and nonmetastatic SLN between these three labeling groups was not different (P = 0.9361). We could not show any difference in the metastatic involvement of SLN in patients in whom preoperative lymphoscintigraphy could visualise the SLN preoperatively compared to those in whom it could not (P = 0.7315). False negativity calculated in our initial series of 36 patients was 0%. Our study showed added value of Blue Dye in detection of metastatic and nonmetastatic SLN.
机译：乳腺癌前哨淋巴结活检是一种新的快速推进的微创手术，可对临床淋巴结阴性的乳腺癌患者进行淋巴结分期，而无需进行彻底的腋窝淋巴结清扫术。使用淋巴闪烁显像和伽马探针时，关于蓝染料的附加价值仍有争议。在我们的系列研究中，由91名连续的浸润性乳腺癌患者由一名外科医生使用淋巴造影，γ探针和Blue Dye进行手术。通过HE和免疫组织化学对前哨淋巴结（SLN）进行组织学检查。淋巴造影成功（81％）。注射蓝染料后，可以在所有91例患者中发现SLN。 35例患者中存在SLN转移。我们检索了128个SLN，其中93个是热蓝色，只有19个热蓝色和16个只有蓝色。这三个标记组之间转移性和非转移性SLN的分布无差异（P = 0.9361）。与术前无法淋巴结显像的患者相比，术前淋巴闪烁显像术可观察到SLN的患者与SLN的转移灶无任何差异（P = 0.7315）。在我们最初的36例患者中计算出的假阴性率为0％。我们的研究表明，蓝染料在转移性和非转移性SLN检测中具有附加价值。

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