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首页> 外文期刊>Journal of experimental & clinical cancer research : >Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses.
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Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses.

机译：通过应用双相电脉冲在具有自发性大肿瘤的伴侣动物中增强化学疗法。

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The objectives of this phase I/II study were: i) to determine whether electrochemotherapy (intralesional bleomycin + electric pulses) could be effective in companion animals with different, large neoplasms compared to chemotherapy (conventional intralesional bleomycin); ii) to identify potential toxicities; iii) to preliminarily assess the electric field requirements. Twenty-two patients received intralesional bleomycin + administration of permeabilizing electric pulses. Specifically, after the injection of the drug, sequences of 8 biphasic electric pulses lasting 50 + 50 micros each, with 1 ms interpulse intervals, were delivered in bursts of 1300 V/cm for cutaneous and soft tissue lesions, and of 800 V/cm for oral mucosal and exposed soft tissue neoplasms, using caliper electrodes. The treatment was well tolerated and side effects were infrequent. Nevertheless, two previously unreported toxicities (drug-induced vasculitis and pulmonary thromboembolism) have been identified. A high response rate (complete remission + partial remission: > 80%), often long lasting (> 40%) was obtained. Furthermore, results of this trial were compared to a subset of veterinary cancer patients treated with bleomycin single agent, observing a remarkable superiority of the combined treatment (p < 0.01). Altogether, results suggest that electrochemotherapy is a potentially advantageous rescue protocol for bulky, even relapsing neoplasms of companion animals. Further investigations in this field might allow developing improved protocols for the treatment of down-staged relapsing cancer in pets as well as in humans.
机译：I / II期研究的目的是：i）确定与化疗（常规病灶内博来霉素）相比，电化学疗法（肌内博莱霉素+电脉冲）在具有不同大肿瘤的伴侣动物中是否有效; ii）查明潜在的毒性; iii）初步评估电场要求。 22名患者接受病灶内博莱霉素+透化电脉冲治疗。具体而言，在注射药物后，以1300 V / cm的脉冲频率（对于皮肤和软组织损伤）和800 V / cm的脉冲频率分别发送8个双相电脉冲序列，每个脉冲持续50 + 50 micros，间隔为1 ms。使用卡尺电极治疗口腔粘膜和裸露的软组织肿瘤。该治疗耐受性好，副作用少见。尽管如此，已经确定了两种以前未报告的毒性（药物引起的血管炎和肺血栓栓塞症）。获得了很高的响应率（完全缓解+部分缓解：> 80％），通常持续时间长（> 40％）。此外，将该试验的结果与接受博来霉素单药治疗的部分兽医癌症患者进行了比较，观察到联合治疗的显着优势（p <0.01）。总体而言，结果表明，电化学疗法对于伴有大体积甚至复发性肿瘤的伴生动物而言是一种潜在的有利挽救方案。在该领域的进一步研究可能允许开发改进的方案，用于治疗宠物以及人类中晚期复发性癌症。

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